Evidence map›Paper›PMID 34256699›Full record

ArticleBMC immunology2021

Type 2 innate lymphoid cells from Id1 transgenic mice alleviate skin manifestations of graft-versus-host disease.

Anand Srinivasan, Sandra Bajana, Aneta Pankow, Carrie Yuen, Rikin K Shah, Xiao-Hong Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 16 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anand SrinivasanPediatric Hematology/Oncology and BMT, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Sandra BajanaArthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK, 73104, USA.
Aneta PankowArthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK, 73104, USA.
Carrie YuenHematology/Oncology and BMT, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Rikin K ShahPediatric Hematology/Oncology and BMT, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Xiao-Hong SunArthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK, 73104, USA. Xiao-Hong-Sun@omrf.org.
Oklahoma Medical Research Foundation · USUniversity of Oklahoma Health Sciences Center · USUniversity of Toronto · CA

Funding

Exploring the thymic origin of group 2 innate lymphoid cellsR01AI126851 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI SUN, XIAO-HONG · 2016 to 2020
$2.7M
NIAID NIH HHS R01 AI126851
6 · The paper itself

Abstract

backgroundAcute graft-versus-host disease (aGVHD) is one of the most common causes of morbidity for patients undergoing allogeneic stem cell transplantation. There is preliminary evidence that activated Group 2 innate lymphoid cells (ILC2s) from wild type (WT) mice reduces the lethality of aGVHD and is effective in treating lower gastrointestinal (GI) tract manifestations of aGVHD. This raises the prospect that ILC2s may be used for cell-based therapy of aGVHD but vigorous investigation is necessary to assess their impacts on different aspects of aGVHD. Genetically engineered mice which either express Id1 protein (Id1

resultsbone marrow transplant was performed by irradiating BALB/c strain of recipient mice and transplanting with bone marrow and T cells from the MHC-disparate C57BL/6 strain. We isolated ILC2s from Id1

conclusionThese findings support the notion that thymus-derived ILC2s from Id1

Indexed as

Hematopoietic Stem Cell TransplantationAnimalsCytokinesDisease Models, AnimalGraft vs Host DiseaseHumansImmunity, InnateInhibitor of Differentiation Protein 1LymphocytesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicSkinTh2 CellsTransplantation, HomologousCytokinesIdb1 protein, mouseInhibitor of Differentiation Protein 1E proteinsGraft-versus-host diseaseId1 transgenic miceType 2 innate lymphoid cells

Identifiers

PMID34256699
PMCPMC8278660
OpenAlexW3180254421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.