Evidence map›Paper›PMID 34256657›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Different roles for the acyl chain and the amine leaving group in the substrate selectivity of

Andrea Ghidini, Laura Scalvini, Francesca Palese, Alessio Lodola, Marco Mor, Daniele Piomelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Andrea GhidiniDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy.ORCID https://orcid.org/0000-0003-1575-975X
Laura ScalviniDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy.ORCID https://orcid.org/0000-0003-3610-527X
Francesca PaleseDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA.ORCID https://orcid.org/0000-0002-8426-8228
Alessio LodolaDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy.ORCID https://orcid.org/0000-0002-8675-1002
Marco MorDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy.ORCID https://orcid.org/0000-0003-0199-1849
Daniele PiomelliDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, USA.ORCID https://orcid.org/0000-0002-2983-774X
University of Parma · ITUniversity of California, Irvine · US

Funding

The lipid amidase NAAA as a therapeutic target for Alzheimer's diseaseRF1AG065329 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI GREEN, KIM, PIOMELLI, DANIELE · 2020 to 2020
$2.3M
NIA NIH HHS RF1 AG065329
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AmidohydrolasesAminesAnimalsDose-Response Relationship, DrugEnzyme InhibitorsMolecular Docking SimulationMolecular StructureRabbitsStructure-Activity RelationshipAmidohydrolasesAminesEnzyme Inhibitorsenzyme kineticmolecular dynamicsN-acylethanolamine acid amidasepalmitoylethanolamidesubstrate selectivity

Identifiers

PMID34256657
PMCPMC8279155
OpenAlexW3180940577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.