Evidence map›Paper›PMID 34256651›Full record

ArticleCephalalgia : an international journal of headache2021

High perceived isolation and reduced social support affect headache impact levels in migraine after the Covid-19 outbreak: A cross sectional survey on chronic and episodic patients.

Chiara Cerami, Chiara Crespi, Sara Bottiroli, Gaia Chiara Santi, Grazia Sances, Marta Allena, Tomaso Vecchi, Cristina Tassorelli

Open access · hybridAbstract read
In one paragraph

Article in Cephalalgia : an international journal of headache, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Network analysis of loneliness, mental, and physical health in Czech adolescents.Child and adolescent psychiatry and mental health · 2025
    Article
  4. Article
  5. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
  6. Article
  7. Article
  8. Risk factors for post-COVID cognitive dysfunctions: the impact of psychosocial vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. NeuroCOVID-19: a critical review.Arquivos de neuro-psiquiatria · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chiara CeramiScuola Universitaria Superiore IUSS Pavia, Pavia, Italy.
Chiara CrespiCognitive Computational Neuroscience Research Unit, IRCCS Mondino Foundation, Pavia, Italy.
Sara BottiroliFaculty of Law, Giustino Fortunato University, Benevento, Italy.
Gaia Chiara SantiScuola Universitaria Superiore IUSS Pavia, Pavia, Italy.
Grazia SancesHeadache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy.
Marta AllenaHeadache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy.
Tomaso VecchiDepartment of Brain and Behavioral Sciences, 19001University of Pavia, University of Pavia, Pavia, Italy.
Cristina TassorelliDepartment of Brain and Behavioral Sciences, 19001University of Pavia, University of Pavia, Pavia, Italy.ORCID 0000-0003-1513-2113
University of Pavia · ITFondazione Istituto Neurologico Nazionale Casimiro Mondino · ITIstituto Universitario di Studi Superiori di Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychosocial variables are key factors influencing psycho-physical equilibrium in migraine patients. Social isolation and vulnerability to stressors may prevent efficient psychological adjustment negatively affecting adaptation to life changes, as that imposed during Covid-19 lockdown. Here, we explored psychosocial dimensions and changes in clinical condition during Covid-19 lockdown in migraine patients, with regard to migraine type and headache impact.

methodsSixty-four migraine patients (32 episodic and 32 chronic) and 64 healthy control subjects were included in a case-control cross-sectional study. A two-step clustering procedure split patients into two clusters, based on the Headache Impact Test. Perceived global distress, loneliness, empathy, and coping levels were compared in groups, as well as changes in clinical condition.

resultsMigraine patients reported higher general loneliness and lower social support compared to healthy control subjects. Emotional loneliness was more marked in patients with higher headache impact. This subgroup of patients more frequently reported changes in the therapeutic and care paths as the perceived cause of the occurrence of motor or extra-motor symptomatology.

conclusionsMigraine patients, especially those more severely affected, proved more vulnerable than healthy control subjects to Covid-19 lockdown. Long-lasting interruption of social interactions may be detrimental in fragile patients that are in need of structured support interventions to maintain psycho-physical wellbeing.

Indexed as

Social IsolationSocial SupportAdultAnxietyCase-Control StudiesCommunicable Disease ControlCOVID-19Cross-Sectional StudiesDisease OutbreaksFemaleHeadacheHumansLonelinessMaleMiddle AgedMigraine Disorderschronic migraineCovid-19episodic migraineheadache impactlonelinessperceived isolation

Identifiers

PMID34256651
PMCPMC8619713
OpenAlexW3182446543

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.