ArticleEnvironment international2021
Non-linear and non-additive associations between the pregnancy metabolome and birthweight.
Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 20 citations in OpenAlex.
- Integrated multi-omics profiling of amniotic fluid identifies predictive biomarkers for fetal growth restriction trajectories.Annals of medicine · 2026Article
- Beyond Feature Selection: Interpretable Machine Learning for Mechanistic Insights in Metabolomics.Biology · 2026Review
- Metabolic maturity patterns in neonates: dissecting the interactive effects of gestational age and birth weight on metabolic profiles.Frontiers in pediatrics · 2026Article
- Multivariate fetal growth trajectory modeling and its association with maternal fatty acids.Scientific reports · 2025Article
- Uterine histotroph and conceptus development. IV. Metabolomic analyses of uterine luminal fluid reveals regulatory landscapes during the peri-implantation period of pregnancy in pigs†.Biology of reproduction · 2025Article
- Windows of susceptibility to air pollution during and surrounding pregnancy in relation to longitudinal maternal measures of adiposity and lipid profiles.Environmental research · 2025Article
- The mediating effect of maternal blood lipids on the association between maternal exposure to PMLipids in health and disease · 2025Article
- Pregnancy as a Susceptible Period to Ambient Air Pollution Exposure on the Maternal Postpartum Metabolome.Environmental science & technology · 2025Article
- Early pregnancy serum PFAS are associated with alterations in the maternal lipidome.Environmental research · 2024Article
- Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.Scientific reports · 2024Article
- Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study.Environmental science & technology · 2023Article
- Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.Pediatric research · 2023Article
- Untargeted and Targeted Blood Lipidomic Signature Profile of Gestational Alcohol Exposure.Nutrients · 2023Article
- Maternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods.Environment international · 2022Article
- CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets.Environment international · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBirthweight is an indicator of fetal growth and environmental-related alterations of birthweight have been linked with multiple disorders and conditions progressing into adulthood. Although a few studies have assessed the association between birthweight and the totality of exogenous exposures and their downstream molecular responses in maternal urine and cord blood; no prior research has considered a) the maternal serum prenatal metabolome, which is enriched for hormones, and b) non-linear and synergistic associations among exposures.
methodsWe measured the maternal serum metabolome during pregnancy using an untargeted metabolomics approach and birthweight for gestational age (BWGA) z-score in 410 mother-child dyads enrolled in the PRogramming of Intergenerational Stress Mechanisms (PRISM) cohort. We leveraged a Bayesian factor analysis for interaction to select the most important metabolites associated with BWGA z-score and to evaluate their linear, non-linear and non-additive associations. We also assessed the primary biological functions of the identified proteins using the MetaboAnalyst, a centralized repository of curated functional information. We compared our findings with those of a traditional metabolite-wide association study (MWAS) in which metabolites are individually associated with BWGA z-score.
resultsAmong 1110 metabolites, 46 showed evidence of U-shape associations with BWGA z-score. Most of the identified metabolites (85%) were lipids primarily enriched for pathways central to energy production, immune function, and androgen and estrogen metabolism, which are essential for pregnancy and parturition processes. Metabolites within the same class, i.e. steroids and phospholipids, showed synergistic relationships with each other.
conclusionsOur results support that the aspects of the maternal metabolome during pregnancy contribute linearly, non-linearly and synergistically to variation in newborn birthweight.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.