Evidence map›Paper›PMID 34256274›Full record

ArticleJournal of psychiatric research2021

Resting posterior alpha power and adolescent major depressive disorder.

Akina Umemoto, Lidia Y X Panier, Sally L Cole, Jürgen Kayser, Diego A Pizzagalli, Randy P Auerbach

Open access · greenAbstract read
In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  14. The Link between Suicidality and Electroencephalography Asymmetry: A Systematic Review and Meta-analysis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Akina UmemotoDepartment of Psychiatry, Columbia University, New York, NY, USA.
Lidia Y X PanierNew York State Psychiatric Institute, New York, NY, USA.
Sally L ColeDepartment of Psychiatry, Columbia University, New York, NY, USA.
Jürgen KayserDepartment of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Diego A PizzagalliDepartment of Psychiatry, Harvard Medical School, USA; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
Randy P AuerbachDepartment of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA; Division of Clinical Developmental Neuroscience, Sackler Institute, USA. Electronic address: rpa2009@cumc.columbia.edu.
Columbia University · USNew York Psychoanalytic Society and Institute · USColumbia University Irving Medical Center · USHarvard University · US

Funding

Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Social Processing Deficits in Remitted Adolescent DepressionR01MH119771 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI AUERBACH, RANDY PATRICK, SHANKMAN, STEWART AARON · 2020 to 2025
$3.7M
Examination of Reward Processing in the Treatment of Adolescent Major DepressionK23MH097786 · NIMH · MCLEAN HOSPITAL · PI AUERBACH, RANDY PATRICK · 2013 to 2016
$686k
MDD Treatment Response and Functional Connectivity of Brain Regions via Reference-free EEG: Further Development and Integration of Biomarkers Using Multisite EMBARC DataR21MH115299 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KAYSER, RALF JÜRGEN · 2018 to 2019
$446k
NIMH NIH HHS K23 MH097786NIMH NIH HHS R01 MH119771NIMH NIH HHS R21 MH115299NIMH NIH HHS R37 MH068376
6 · The paper itself

Abstract

For several decades, resting electroencephalogram (EEG) alpha oscillations have been used to characterize neurophysiological alterations related to major depressive disorder. Prior research has generally focused on frontal alpha power and asymmetry despite resting alpha being maximal over posterior electrode sites. Research in depressed adults has shown evidence of hemispheric asymmetry for posterior alpha power, however, the resting posterior alpha-depression link among adolescents remains unclear. To clarify the role of posterior alpha among depressed adolescents, the current study acquired eyes-closed 128-channel resting EEG data from 13 to 18 year-old depressed (n = 31) and healthy (n = 35) female adolescents. Results indicated a significant group by hemisphere interaction, as depressed adolescents exhibited significantly larger posterior alpha (i.e., lower brain activity) over the right versus left hemisphere, whereas healthy adolescents showed no hemispheric differences. Relatively greater alpha over the right versus left hemisphere correlated with depression symptoms, anhedonia symptoms, rumination, and self-criticism. Further, depressed adolescents had reduced overall posterior alpha compared to healthy youth; though, no associations with symptoms and related traits emerged. Resting posterior alpha may be a promising neurophysiological index of adolescent depression, and more broadly, may relate to risk factors characterized by enhanced perseveration.

Indexed as

Major Depressive DisorderAdolescentAdultAlpha RhythmElectroencephalographyFemaleHumansRestRisk FactorsAdolescenceAlpha asymmetryAnhedoniaMajor depressionRuminationSelf-criticismSuicidal behaviorsSuicidal ideation

Identifiers

PMID34256274
PMCPMC8364881
OpenAlexW3180480832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.