ArticleCurrent biology : CB2021
Genome-scale sequencing and analysis of human, wolf, and bison DNA from 25,000-year-old sediment.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026Review
- A Roadmap for Using Hybridisation Capture-Based Target Enrichment of Ancient Environmental DNA in Palaeoecology.Molecular ecology resources · 2026Review
- Investigating ancient human DNA preservation on cave walls and in rock art.Nature communications · 2026Article
- Ancient environmental genome reveals a migratory brown bear individual in Early Holocene Scandinavia.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- sedimix: a workflow for the analysis of hominin nuclear DNA sequences from sediments.Bioinformatics (Oxford, England) · 2026Article
- Continent-wide view of genomic diversity and divergence in the wolves of Asia.Communications biology · 2025Article
- Quick Analysis of Sedimentary Ancient DNA Using quicksand.Molecular biology and evolution · 2025Article
- Can Amplicon Sequencing Be Replaced by Metagenomics for Biodiversity Inventories?Molecular ecology resources · 2025Article
- Bone Adhered Sediments as a Source of Target and Environmental DNA and Proteins.Molecular biology and evolution · 2025Article
- Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens.Scientific reports · 2025Article
- Pre-processing of paleogenomes: mitigating reference bias and postmortem damage in ancient genome data.Genome biology · 2025Article
- A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain.Nature communications · 2025Article
- Article
- soibean: High-Resolution Taxonomic Identification of Ancient Environmental DNA Using Mitochondrial Pangenome Graphs.Molecular biology and evolution · 2024Article
- Maximizing efficiency in sedimentary ancient DNA analysis: a novel extract pooling approach.Scientific reports · 2024Article
- Sediment DNA can revolutionize archaeology-if it is used the right way.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cervidae antlers exploited to manufacture prehistoric tools and hunting implements as a reliable source of ancient DNA.Heliyon · 2024Article
- Archaeology meets environmental genomics: implementing sedaDNA in the study of the human past.Archaeological and anthropological sciences · 2024Article
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19 authors at 9 institutions in 8 countries.
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Abstract
Cave sediments have been shown to preserve ancient DNA but so far have not yielded the genome-scale information of skeletal remains. We retrieved and analyzed human and mammalian nuclear and mitochondrial environmental "shotgun" genomes from a single 25,000-year-old Upper Paleolithic sediment sample from Satsurblia cave, western Georgia:first, a human environmental genome with substantial basal Eurasian ancestry, which was an ancestral component of the majority of post-Ice Age people in the Near East, North Africa, and parts of Europe; second, a wolf environmental genome that is basal to extant Eurasian wolves and dogs and represents a previously unknown, likely extinct, Caucasian lineage; and third, a European bison environmental genome that is basal to present-day populations, suggesting that population structure has been substantially reshaped since the Last Glacial Maximum. Our results provide new insights into the Late Pleistocene genetic histories of these three species and demonstrate that direct shotgun sequencing of sediment DNA, without target enrichment methods, can yield genome-wide data informative of ancestry and phylogenetic relationships.
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