Evidence map›Paper›PMID 34255934›Full record

ArticleInfluenza and other respiratory viruses2021

Defining the seasonality of respiratory syncytial virus around the world: National and subnational surveillance data from 12 countries.

Lisa Staadegaard, Saverio Caini, Sonam Wangchuk, Binay Thapa, Walquiria Aparecida Ferreira de Almeida, Felipe Cotrim de Carvalho, Rodrigo A Fasce, Patricia Bustos, Jan Kyncl, Ludmila Novakova and 19 more

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Determining the timing of respiratory syncytial virus (RSV) epidemics: a systematic review, 2016 to 2021; method categorisation and identification of influencing factors.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Pooled it
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  15. [Epidemiological characteristics of respiratory syncytial virus infection in children in Hebei Province].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 14 institutions in 13 countries.

Lisa StaadegaardNivel (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.ORCID 0000-0002-6985-3541
Saverio CainiNivel (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.ORCID 0000-0002-2262-1102
Sonam WangchukRoyal Centre for Disease Control, Ministry of Health, Thimphu, Bhutan.
Binay ThapaRoyal Centre for Disease Control, Ministry of Health, Thimphu, Bhutan.
Walquiria Aparecida Ferreira de AlmeidaDepartment of Immunization and Communicable Diseases, Ministry of Health, Brasilia, Brazil.
Felipe Cotrim de CarvalhoDepartment of Immunization and Communicable Diseases, Ministry of Health, Brasilia, Brazil.
Rodrigo A FasceSubdepartamento Enfermedades Virales, Instituto de Salud Pública de Chile, Santiago, Chile.
Patricia BustosSección Virus Respiratorios, Subdepartamento Enfermedades Virales, Instituto de Salud Publica de Chile, Santiago, Chile.
Jan KynclDepartment of Infectious Diseases Epidemiology, National Institute of Public Health, Prague, Czech Republic.ORCID 0000-0002-0804-2729
Ludmila NovakovaNational Reference Laboratory for Influenza and Other Respiratory Viruses, National Institute of Public Health, Prague, Czech Republic.
Alfredo Bruno CaicedoUniversidad Agraria del Ecuador, Guayaquil, Ecuador.
Domenica Joseth de Mora ColomaInstituto Nacional de Investigación en Salud Pública (INSPI), Centro de Referencia Nacional de Influenza y otros Virus Respiratorios, Guayaquil, Ecuador.
Adam MeijerNational Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Mariëtte HooiveldNivel (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.
Q Sue HuangInstitute of Environmental Science and Research Limited (ESR), National Centre for Biosecurity and Infectious Disease (NCBID), Upper Hutt, New Zealand.
Tim WoodInstitute of Environmental Science and Research Limited (ESR), National Centre for Biosecurity and Infectious Disease (NCBID), Upper Hutt, New Zealand.
Raquel GuiomarInstituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.
Ana Paula RodriguesInstituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.
Vernon Jian Ming LeeMinistry of Health, Singapore.
Li Wei AngMinistry of Health, Singapore.
Cheryl CohenCentre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0003-0376-2302
Jocelyn MoyesCentre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.
Amparo LarrauriNational Centre of Epidemiology, CIBER Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III (ISCIII), Madrid, Spain.ORCID 0000-0002-1704-2245
Concepción Delgado-SanzNational Centre of Epidemiology, CIBER Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III (ISCIII), Madrid, Spain.
Clarisse DemontSanofi Pasteur, Lyon, France.
Mathieu BangertSanofi Pasteur, Lyon, France.
Michel DückersNivel (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.
Jojanneke van SummerenNivel (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.
John PagetNivel (Netherlands Institute for Health Services Research), Utrecht, The Netherlands.ORCID 0000-0002-1503-2481
Netherlands Institute for Health Services Research · NLInstituto de Salud Carlos III · ESInstituto de Salud Pública de Chile · CLInstituto Nacional de Investigación en Salud Pública · ECMinistério da Saúde · BRMinistry of Health · SGNational Institute of Health Dr. Ricardo Jorge · PTNew Zealand Institute for Public Health and Forensic Science · NZRoyal Centre for Disease Control · BTSanofi (France) · FRUniversity of the Witwatersrand · ZACharles University · CZNational Influenza Center · MNNational Institute for Public Health and the Environment · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) infections are one of the leading causes of lower respiratory tract infections and have a major burden on society. For prevention and control to be deployed effectively, an improved understanding of the seasonality of RSV is necessary.

objectivesThe main objective of this study was to contribute to a better understanding of RSV seasonality by examining the GERi multi-country surveillance dataset.

methodsRSV seasons were included in the analysis if they contained ≥100 cases. Seasonality was determined using the "average annual percentage" method. Analyses were performed at a subnational level for the United States and Brazil.

resultsWe included 601 425 RSV cases from 12 countries. Most temperate countries experienced RSV epidemics in the winter, with a median duration of 10-21 weeks. Not all epidemics fit this pattern in a consistent manner, with some occurring later or in an irregular manner. More variation in timing was observed in (sub)tropical countries, and we found substantial differences in seasonality at a subnational level. No association was found between the timing of the epidemic and the dominant RSV subtype.

conclusionsOur findings suggest that geographical location or climatic characteristics cannot be used as a definitive predictor for the timing of RSV epidemics and highlight the need for (sub)national data collection and analysis.

Indexed as

EpidemicsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsHumansInfantSeasonsUnited Statesepidemiologyrespiratory syncytial virusseasonalitysurveillance

Identifiers

PMID34255934
PMCPMC8542954
OpenAlexW3179488699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.