ArticleThe Journal of nutrition2021
Whole- and Refined-Grain Consumption and Longitudinal Changes in Cardiometabolic Risk Factors in the Framingham Offspring Cohort.
Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Trial
- A Culturally Sensitive and Theory-Based Intervention on Prevention and Management of Diabetes: A Cluster Randomized Control Trial.Nutrients · 2022Trial
- Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators.Clinical nutrition (Edinburgh, Scotland) · 2022Trial
- Dietary Laver Intake and Risk of Incident Abdominal Obesity Among Korean Adults: An 18-Year Prospective Cohort Study.Nutrients · 2026Observational
- Diet in the General United States Asian American Population: A Scoping Review.Current developments in nutrition · 2026Review
- Investigating the Role of Carbohydrates Quantity and Quality in the Incidence of Metabolic Syndrome: A Two-Year Cohort Study : Short title: Fat and Sleep Quality.Galen medical journal · 2026Article
- Racial/ethnic-derived maternal diets predict birth outcomes better than a diet derived from a combined sample among Hispanic/Latina and non-Hispanic White pregnant individuals in the ECHO Cohort.Nutrition (Burbank, Los Angeles County, Calif.) · 2025Article
- Associations of diet composition and quality with continuous glucose monitor-derived glycemic metrics in a community-based cohort.The American journal of clinical nutrition · 2025Article
- Impact of carbohydrate quality on the association between low-carbohydrate diet scores and longitudinal changes of cardiometabolic risk factors.Nutrition journal · 2025Article
- The cross-sectional association between ultra-processed food intake and metabolic dysfunction-associated steatotic liver disease.Clinical nutrition ESPEN · 2025Article
- Dietary patterns to promote cardiometabolic health.Nature reviews. Cardiology · 2025Review
- Investigating the impact of dietary guidelines transition on cardiometabolic risk profile: a forensic analysis using diet quality metrics.Scientific reports · 2024Article
- Metabolite Profiles of Plant-Based Diets and Cardiometabolic Risk in the Mediators of Atherosclerosis in South Asians Living in America Study.The Journal of nutrition · 2024Article
- Enhanced Elderberry Snack Bars: A Sensory, Nutritional, and Rheological Evaluation.Foods (Basel, Switzerland) · 2023Article
- Effect of weight change on the association between overall and source of carbohydrate intake and risk of metabolic syndrome: Tehran lipid and glucose study.Nutrition & metabolism · 2023Article
- Article
- Exploring the association of dietary patterns with the risk of hypertension using principal balances analysis and principal component analysis.Public health nutrition · 2023Article
- White Meat Consumption and Cardiometabolic Risk Factors: A Review of Recent Prospective Cohort Studies.Nutrients · 2022Review
- Proteomics, dietary intake, and changes in cardiometabolic health within a behavioral weight-loss intervention: A pilot study.Obesity (Silver Spring, Md.) · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGreater whole grain (WG) consumption is associated with reduced risk of cardiovascular disease (CVD); however, few prospective studies have examined WG or refined grain (RG) intake and intermediate cardiometabolic risk factors.
objectivesWe examined the longitudinal association between WG and RG intake on changes in waist circumference (WC); fasting HDL cholesterol, triglyceride, and glucose concentrations; and blood pressure.
methodsSubjects were participants in the Framingham Offspring cohort study [n = 3121; mean ± SD baseline age: 54.9 ± 0.2 y; BMI (kg/m2) 27.2 ± 0.1]. FFQ, health, and lifestyle data were collected approximately every 4 y over a median 18-y follow-up. Repeated measure mixed models were used to estimate adjusted mean changes per 4-y interval in risk factors across increasing categories of WG or RG intake.
resultsGreater WG intake was associated with smaller increases in WC (1.4 ± 0.2 compared with 3.0 ± 0.1 cm in the highest compared with the lowest category, respectively; P-trend < 0.001), fasting glucose concentration (0.7 ± 0.4 compared with 2.6 ± 0.2 mg/dL; P-trend < 0.001), and systolic blood pressure (SBP; 0.2 ± 0.5 compared with 1.4 ± 0.3 mm Hg; P-trend < 0.001) per 4-y interval. When stratified by sex, a stronger association with WC was observed among females than males. Higher intake of WG was associated with greater increases in HDL cholesterol and declines in triglyceride concentrations; however, these differences did not remain significant after adjustment for change in WC. Conversely, greater RG intake was associated with greater increases in WC (2.7 ± 0.2 compared with 1.8 ± 0.1 cm, P-trend < 0.001) and less decline in triglyceride concentration (-0.3 ± 1.3 compared with -7.0 ± 0.7 mg/dL, P-trend < 0.001).
conclusionsAmong middle- to older-age adults, replacing RG with WG may be an effective dietary modification to attenuate abdominal adiposity, dyslipidemia, and hyperglycemia over time, thereby reducing the risk of cardiometabolic diseases.
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