ArticlePloS one2021
Prediction of 28-day mortality in critically ill patients with COVID-19: Development and internal validation of a clinical prediction model.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Prognostic models in COVID-19 infection that predict severity: a systematic review.European journal of epidemiology · 2023Pooled it
- Nasotracheal Versus Orotracheal Intubation in Critically Ill COVID-19 Patients: A Retrospective Study.International journal of general medicine · 2026Article
- Deep learning-based lung cancer risk assessment using chest computed tomography images without pulmonary nodules ≥8 mm.Translational lung cancer research · 2025Article
- Transforaminal Steroid Injection After Dorsal Root Ganglion Pulsed Radiofrequency (DRG-PRF): Impact on Pain Intensity and Disability.Pain and therapy · 2024Article
- Back to the future: the novel art of digital auscultation applied in a prospective observational study of critically ill Covid-19 patients.Pneumonia (Nathan Qld.) · 2024Article
- Acute Kidney Injury in the Context of COVID-19: An Analysis in Hospitalized Mexican Patients.Infectious disease reports · 2024Article
- External Validation of Prognostic Models in Critical Care: A Cautionary Tale From COVID-19 Pneumonitis.Critical care explorations · 2024Article
- A Transcriptomic Severity Classifier IMX-SEV-3b to Predict Mortality in Intensive Care Unit Patients with COVID-19: A Prospective Observational Pilot Study.Journal of clinical medicine · 2023Article
- Software-Based Assessment of Well-Aerated Lung at CT for Quantification of Predicted Pulmonary Function in Resected NSCLC.Life (Basel, Switzerland) · 2023Article
- Assessment of risk scores to predict mortality of COVID-19 patients admitted to the intensive care unit.Frontiers in medicine · 2023Article
- Predictors of Mortality Among Children with Confirmed and Suspected Cases of COVID-19 in East Java, Indonesia.Journal of multidisciplinary healthcare · 2023Article
- Intestinal Fatty Acid Binding Protein (I-FABP) as a Prognostic Marker in Critically Ill COVID-19 Patients.Pathogens (Basel, Switzerland) · 2022Article
- Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia.Annals of medicine · 2022Article
- Analysis of CT signs, radiomic features and clinical characteristics for delta variant COVID-19 patients with different vaccination status.BMC medical imaging · 2022Article
- Use of rotational thromboelastometry to predict the outcome of COVID-19 patients: A retrospective observational study.Journal of anaesthesiology, clinical pharmacology · 2022Article
- The modified NUTRIC score (mNUTRIC) is associated with increased 28-day mortality in critically ill COVID-19 patients: Internal validation of a prediction model.Clinical nutrition ESPEN · 2022Article
- Development and Validation of the Acute PNeumonia Early Assessment Score for Safely Discharging Low-Risk SARS-CoV-2-Infected Patients from the Emergency Department.Journal of clinical medicine · 2022Article
- Observational
- Predictors for adult COVID-19 hospitalized inpatient mortality rate in North West Ethiopia.SAGE open medicine · 2022Article
- Risk factors of early mortality among COVID-19 deceased patients in Addis Ababa COVID-19 care centers, Ethiopia.PloS one · 2022Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19 pandemic has rapidly required a high demand of hospitalization and an increased number of intensive care units (ICUs) admission. Therefore, it became mandatory to develop prognostic models to evaluate critical COVID-19 patients. MATERIALS AND
methodsWe retrospectively evaluate a cohort of consecutive COVID-19 critically ill patients admitted to ICU with a confirmed diagnosis of SARS-CoV-2 pneumonia. A multivariable Cox regression model including demographic, clinical and laboratory findings was developed to assess the predictive value of these variables. Internal validation was performed using the bootstrap resampling technique. The model's discriminatory ability was assessed with Harrell's C-statistic and the goodness-of-fit was evaluated with calibration plot.
results242 patients were included [median age, 64 years (56-71 IQR), 196 (81%) males]. Hypertension was the most common comorbidity (46.7%), followed by diabetes (15.3%) and heart disease (14.5%). Eighty-five patients (35.1%) died within 28 days after ICU admission and the median time from ICU admission to death was 11 days (IQR 6-18). In multivariable model after internal validation, age, obesity, procaltitonin, SOFA score and PaO2/FiO2 resulted as independent predictors of 28-day mortality. The C-statistic of the model showed a very good discriminatory capacity (0.82).
conclusionsWe present the results of a multivariable prediction model for mortality of critically ill COVID-19 patients admitted to ICU. After adjustment for other factors, age, obesity, procalcitonin, SOFA and PaO2/FiO2 were independently associated with 28-day mortality in critically ill COVID-19 patients. The calibration plot revealed good agreements between the observed and expected probability of death.
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