ArticleJCI insight2021
Cervicovaginal microbiota and metabolome predict preterm birth risk in an ethnically diverse cohort.
Article in JCI insight, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of emergency/nonemergency cervical cerclage on the vaginal microbiome of pregnant women with cervical incompetence.Frontiers in cellular and infection microbiology · 2023Trial
- Complement and neutrophils are actively involved at the cervicovaginal interface in cases of adverse microbial composition, cervical shortening and spontaneous preterm birth.NPJ biofilms and microbiomes · 2026Article
- The vaginal microbiome in pregnancy and preterm birth: mechanisms, disparities, and therapeutic opportunities.NPJ biofilms and microbiomes · 2026Review
- TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis.Nature communications · 2026Article
- Investigation into biomarkers to predict preterm birth (INSIGHT): a longitudinal UK pregnancy cohort for spontaneous preterm birth research.Frontiers in reproductive health · 2026Article
- Integrated metagenomic and metabolomic profiling of spontaneous preterm birth in Chinese women.Frontiers in microbiology · 2026Article
- The intersection of cervicovaginal microbiota and cervical length in predicting adverse perinatal outcomes at preterm birth risk.BMC pregnancy and childbirth · 2025Article
- Increased vaginalmSystems · 2025Article
- Multi-parametric quantitative evaluation of murine cervical remodeling during pregnancy and postpartum.Scientific reports · 2025Article
- Vaginal host immune-microbiome-metabolite interactions associated with spontaneous preterm birth in a predominantly white cohort.NPJ biofilms and microbiomes · 2025Article
- Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation.mBio · 2024Article
- INSIGHT-2: mechanistic studies into pregnancy complications and their impact on maternal and child health-study protocol.Reproductive health · 2024Article
- The Immunomodulatory Role of Regulatory T Cells in Preterm Birth and Associated Pregnancy Outcomes.International journal of molecular sciences · 2024Review
- Elafin level in lichen planus.Archives of dermatological research · 2024Article
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- Article
- The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth.Microbiome · 2024Article
- Review
- Dysbiotic Vaginal Microbiota Induces Preterm Birth Cascade via Pathogenic Molecules in the Vagina.Metabolites · 2024Article
- Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
The syndrome of spontaneous preterm birth (sPTB) presents a challenge to mechanistic understanding, effective risk stratification, and clinical management. Individual associations between sPTB, self-reported ethnic ancestry, vaginal microbiota, metabolome, and innate immune response are known but not fully understood, and knowledge has yet to impact clinical practice. Here, we used multi-data type integration and composite statistical models to gain insight into sPTB risk by exploring the cervicovaginal environment of an ethnically heterogenous pregnant population (n = 346 women; n = 60 sPTB < 37 weeks' gestation, including n = 27 sPTB < 34 weeks). Analysis of cervicovaginal samples (10-15+6 weeks) identified potentially novel interactions between risk of sPTB and microbiota, metabolite, and maternal host defense molecules. Statistical modeling identified a composite of metabolites (leucine, tyrosine, aspartate, lactate, betaine, acetate, and Ca2+) associated with risk of sPTB < 37 weeks (AUC 0.752). A combination of glucose, aspartate, Ca2+, Lactobacillus crispatus, and L. acidophilus relative abundance identified risk of early sPTB < 34 weeks (AUC 0.758), improved by stratification by ethnicity (AUC 0.835). Increased relative abundance of L. acidophilus appeared protective against sPTB < 34 weeks. By using cervicovaginal fluid samples, we demonstrate the potential of multi-data type integration for developing composite models toward understanding the contribution of the vaginal environment to risk of sPTB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.