Evidence map›Paper›PMID 34255542›Full record

ReviewAnnual review of virology2021

Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals.

Joshua M Kirsch, Robert S Brzozowski, Dominick Faith, June L Round, Patrick R Secor, Breck A Duerkop

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Joshua M KirschDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA; email: breck.duerkop@cuanschutz.edu.
Robert S BrzozowskiDivision of Biological Sciences, University of Montana, Missoula, Montana 59812, USA; email: patrick.secor@mso.umt.edu.
Dominick FaithDivision of Biological Sciences, University of Montana, Missoula, Montana 59812, USA; email: patrick.secor@mso.umt.edu.
June L RoundDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA; email: june.round@path.utah.edu.
Patrick R SecorDivision of Biological Sciences, University of Montana, Missoula, Montana 59812, USA; email: patrick.secor@mso.umt.edu.
Breck A DuerkopDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA; email: breck.duerkop@cuanschutz.edu.
University of Montana · USUniversity of Colorado Denver · USUniversity of Utah · US

Funding

Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP20GM103546 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2012 to 2021
$19.2M
Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine.R01AI141479 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DUERKOP, BRECK A · 2018 to 2025
$4.4M
Bacteriophage pathobiology of inflammatory bowel diseaseR01DK124317 · NIDDK · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2020 to 2023
$2.5M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
The interplay of the immune system, and microbiome in determining outcome of respiratory viral infections in hematopoietic cell transplant recipients and in patients with leukemia and lung cancerR01CA246368 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BATISTA, MARJORIE, CHEMALY, ROY F. · 2020 to 2023
$518k
Targeting a ubiquitous spirochete bacteriophage to prevent Lyme diseaseR21AI151597 · NIAID · UNIVERSITY OF MONTANA · PI SECOR, PATRICK R · 2020 to 2021
$399k
NCI NIH HHS R01 CA246368NIAID NIH HHS R01 AI141479NIAID NIH HHS R21 AI151597NIAID NIH HHS T32 AI052066NIDDK NIH HHS R01 DK124317NIGMS NIH HHS P20 GM103546
6 · The paper itself

Abstract

Bacteria and their viruses (bacteriophages or phages) interact antagonistically and beneficially in polymicrobial communities such as the guts of animals. These interactions are multifaceted and are influenced by environmental conditions. In this review, we discuss phage-bacteria interactions as they relate to the complex environment of the gut. Within the mammalian and invertebrate guts, phages and bacteria engage in diverse interactions including genetic coexistence through lysogeny, and phages directly modulate microbiota composition and the immune system with consequences that are becoming recognized as potential drivers of health and disease. With greater depth of understanding of phage-bacteria interactions in the gut and the outcomes, future phage therapies become possible.

Indexed as

BacteriophagesGastrointestinal MicrobiomeAnimalsBacteriaInvertebratesMammalsarthropod gutbacteriophageIBDintestinal viromephage-bacteria interaction

Identifiers

PMID34255542
PMCPMC8484061
OpenAlexW3180673505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.