ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Living Arrangements and Cognitive Impairment Among Mexican American Older Adults: Nativity Differences.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Identifying the optimal combinations of modifiable dementia risk factors to target in multidomain intervention - Three-year longitudinal findings from the Canadian longitudinal study on aging.The journal of prevention of Alzheimer's disease · 2025Article
- Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study.The journal of prevention of Alzheimer's disease · 2025Article
- Sex Differences in Mortality and Health Care Utilization After Dementia Diagnosis.JAMA neurology · 2025Article
- The impact of modifiable risk factor reduction on future dementia burden: a microsimulation modeling study.European journal of epidemiology · 2025Article
- Translating lifestyle interventions for optimal brain health in Africa.Nature reviews. Neurology · 2025Review
- Sex differences in cognitive trajectories and practice effects in a cohort of older Londoners: The role of risk factors.Journal of Alzheimer's disease : JAD · 2025Article
- Temporal trends in sex differences in dementia care-results from the Swedish registry for cognitive/dementia disorders, SveDem.Scientific reports · 2025Article
- Effects of self-managed lifestyle behavioral changes on cognitive impairment control in Chinese older adults: a population-based prospective study.Translational psychiatry · 2025Article
- Alzheimer disease seen through the lens of sex and gender.Nature reviews. Neurology · 2025Review
- Modifiable Risk Factors for Cognitive Decline in Community-Dwelling Older Adults Differ by Sex and APOE4.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions.Alzheimer's research & therapy · 2025Review
- Review
- Global burden of dementia in younger people: an analysis of data from the 2021 Global Burden of Disease Study.EClinicalMedicine · 2024Article
- Intrinsic aerobic capacity modulates Alzheimer's disease pathological hallmarks, brain mitochondrial function and proteome during aging.GeroScience · 2024Article
- Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention.Nutrition journal · 2024Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEvidence on sex differences in the risk for dementia has been mixed. The goal was to assess sex differences in the development of dementia, and in the effects of a lifestyle intervention.
methodsTwo strategies were adopted, one using combined data from three large Nordic population-based cohort studies (n = 2289), adopting dementia as outcome, and 2-year multidomain lifestyle intervention (n = 1260), adopting cognitive change as outcome.
resultsThere was higher risk for dementia after age 80 years in women. The positive effects of the lifestyle intervention on cognition did not significantly differ between men and women. Sex-specific analyses suggested that different vascular, lifestyle, and psychosocial risk factors are important for women and men in mid- and late-life.
conclusionWomen had higher risk for dementia among the oldest individuals. Lifestyle interventions may be effectively implemented among older men and women.
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Registered trials
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