Evidence map›Paper›PMID 34255379›Full record

ArticleJournal of medical virology2021

Rapid immunoassay and clinical evaluation of the SARS-CoV-2 antibody assay on the real express-6 analyzer.

Shun Zhang, Yingjun Ning, Yejing Rong, Yaxing Nie, Zi Xiong, Rui Li, Tong Jin, Ting Cai

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Shun ZhangDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Yingjun NingDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Yejing RongDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Yaxing NieDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Zi XiongDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Rui LiNingboziyuan Medical Devices Co., Ltd., Ningbo, China.
Tong JinDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Ting CaiDepartment of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Blood Center of Zhejiang Province · CNUniversity of Chinese Academy of Sciences · CNNingbo No. 2 Hospital · CNThe Medical Device (United Kingdom) · GB

Funding

Ningbo HwaMei Key Research Fund [grant number 2020HMZD23]Ningbo HwaMei Research Fund [grant number 2020HMZD25]Ningbo Science and Technology Plan Project [grant number 2020C50001]Zhejiang Medicine and Health Science and Technology Project [grant number 2021PY021]
6 · The paper itself

Abstract

We developed a rapid and simple magnetic chemiluminescence enzyme immunoassay on the Real Express-6 analyzer, which could simultaneously detect immunoglobulin G and immunoglobulin M antibodies against SARS-CoV-2 virus in human blood within 18 min, and which could be used to detect clinical studies to verify its clinical efficacy. We selected blood samples from 185 COVID-19 patients confirmed by polymerase chain reaction and 271 negative patients to determine the clinical detection sensitivity, specificity, stability, and precision of this method. Meanwhile, we also surveyed the dynamic variance of viral antibodies during SARS-CoV-2 infection. This rapid immunoassay test has huge potential benefits for rapid screening of SARS-CoV-2 infection and may help clinical drug and vaccine development.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, ViralCOVID-19COVID-19 Serological TestingCross ReactionsEarly DiagnosisFemaleHumansImmunoassayImmunoglobulin GImmunoglobulin MLuminescent MeasurementsMaleAntibodies, ViralImmunoglobulin GImmunoglobulin MantibodyimmunoassayrapidSARS-CoV-2

Identifiers

PMID34255379
PMCPMC8426859
OpenAlexW3182198638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.