Evidence map›Paper›PMID 34255250›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2021

The role of cysteine in tellurate reduction and toxicity.

Jennifer L Goff, Maxim I Boyanov, Kenneth M Kemner, Nathan Yee

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jennifer L GoffDepartment of Earth and Planetary Sciences, Rutgers University, Piscataway, NJ, 08854, USA. JLGoff@uga.edu.ORCID 0000-0002-9089-9632
Maxim I BoyanovBulgarian Academy of Sciences, Institute of Chemical Engineering, 1113, Sofia, Bulgaria.
Kenneth M KemnerBiosciences Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
Nathan YeeDepartment of Earth and Planetary Sciences, Rutgers University, Piscataway, NJ, 08854, USA.
Argonne National Laboratory · USRutgers, The State University of New Jersey · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tellurium oxyanion tellurate is toxic to living organisms even at low concentrations; however, its mechanism of toxicity is poorly understood. Here, we show that exposure of Escherichia coli K-12 to tellurate results in reduction to elemental tellurium (Te[0]) and the formation of intracellular reactive oxygen species (ROS). Toxicity assays performed with E. coli indicated that pre-oxidation of the intracellular thiol pools increases cellular resistance to tellurate-suggesting that intracellular thiols are important in tellurate toxicity. X-ray absorption spectroscopy experiments demonstrated that cysteine reduces tellurate to elemental tellurium. This redox reaction was found to generate superoxide anions. These results indicate that tellurate reduction to Te(0) by cysteine is a source of ROS in the cytoplasm of tellurate-exposed cells.

Indexed as

CysteineEscherichia coli K12Oxidation-ReductionOxidative StressTelluriumCysteineTelluriumtellurous acidEscherichia coliMetalloidsTellurateTellurate toxicityTellurium

Identifiers

PMID34255250
OpenAlexW3179839470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.