Evidence map›Paper›PMID 34255197›Full record

ArticleBrain informatics2021

Evaluating deep learning EEG-based mental stress classification in adolescents with autism for breathing entrainment BCI.

Avirath Sundaresan, Brian Penchina, Sean Cheong, Victoria Grace, Antoni Valero-Cabré, Adrien Martel

Open access · goldAbstract read
In one paragraph

Article in Brain informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  3. Application and Research Progress of BCI in Post-Stroke Psychiatric Disorders: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Avirath SundaresanThe Nueva School, San Mateo, CA, 94033, USA.ORCID http://orcid.org/0000-0001-6328-8695
Brian PenchinaThe Nueva School, San Mateo, CA, 94033, USA.ORCID http://orcid.org/0000-0001-6774-7174
Sean CheongThe Nueva School, San Mateo, CA, 94033, USA.ORCID http://orcid.org/0000-0002-8725-1907
Victoria GraceMuvik Labs, LLC, Locust Valley, NY, 11560, USA.ORCID http://orcid.org/0000-0003-1427-4996
Antoni Valero-CabréCenter for Computer Research in Music and Acoustics, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-5033-2279
Adrien MartelCognitive Neuroscience and Information Technology Research Program, Open University of Catalonia (UOC), Barcelona, Spain. adrien.martel@icm-institute.org.ORCID http://orcid.org/0000-0002-6245-4206
Centre National de la Recherche Scientifique · FRBoston University · US

Funding

Agence Nationale de la Recherche Flag-era-JTC-2017Agence Nationale de la Recherche OSCILOSCOPUSH2020 Marie Sklodowska-Curie Actions EU project 898813-CLONESA-DLV-898813
6 · The paper itself

Abstract

Mental stress is a major individual and societal burden and one of the main contributing factors that lead to pathologies such as depression, anxiety disorders, heart attacks, and strokes. Given that anxiety disorders are one of the most common comorbidities in youth with autism spectrum disorder (ASD), this population is particularly vulnerable to mental stress, severely limiting overall quality of life. To prevent this, early stress quantification with machine learning (ML) and effective anxiety mitigation with non-pharmacological interventions are essential. This study aims to investigate the feasibility of exploiting electroencephalography (EEG) signals for stress assessment by comparing several ML classifiers, namely support vector machine (SVM) and deep learning methods. We trained a total of eleven subject-dependent models-four with conventional brain-computer interface (BCI) methods and seven with deep learning approaches-on the EEG of neurotypical (n=5) and ASD (n=8) participants performing alternating blocks of mental arithmetic stress induction, guided and unguided breathing. Our results show that a multiclass two-layer LSTM RNN deep learning classifier is capable of identifying mental stress from ongoing EEG with an overall accuracy of 93.27%. Our study is the first to successfully apply an LSTM RNN classifier to identify stress states from EEG in both ASD and neurotypical adolescents, and offers promise for an EEG-based BCI for the real-time assessment and mitigation of mental stress through a closed-loop adaptation of respiration entrainment.

Indexed as

AutismBreathing entrainmentDeep learningEEGMental stress

Identifiers

PMID34255197
PMCPMC8276906
OpenAlexW3106553357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.