Evidence map›Paper›PMID 34255179›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Correlates of financial toxicity in adult cancer patients and their informal caregivers.

Gelareh Sadigh, Jeffrey Switchenko, Kathryn E Weaver, Deema Elchoufi, Jane Meisel, Mehmet Asim Bilen, David Lawson, David Cella, Bassel El-Rayes, Ruth Carlos

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06134180 (An AI-Embedded Intervention to Promote Financial Wellbeing Among Latino Family Caregivers), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06134180 nacompletednot on this mapstarted 2024, after this paper: background citation

An AI-Embedded Intervention to Promote Financial Wellbeing Among Latino Family Caregivers

TypeinterventionalSponsorCase Western Reserve UniversityRan2024 to 2025Enrolled14ConditionsAlzheimer Disease, Dementia, Caregiver Burden, Financial StressArmsCONFIDENCE-AI
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Financial toxicity among families of children with cancer: a qualitative systematic review and meta-aggregation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Pooled it
  3. Financial Toxicity Monitoring in a Randomized Controlled Trial of Patient-Reported Outcomes During Cancer Treatment (Alliance AFT-39).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. The influence of family resilience and benefit finding on the financial toxicity of primary caregivers of patients with advanced cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  9. Financial toxicity among breast cancer survivors receiving care during the pandemic.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  10. Exploring associations between area deprivation index, income, and loneliness among cancer caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Family Experiences of Financial Hardship after Critical Illness.Annals of the American Thoracic Society · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Gelareh SadighDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, Suite BG20, Atlanta, GA, 30322, USA. g.sadigh@emory.edu.ORCID http://orcid.org/0000-0003-3233-1878
Jeffrey SwitchenkoDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Kathryn E WeaverDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Deema ElchoufiDepartment of Family Medicine and Community Health, Duke University School of Medicine, Durham, NC, USA.
Jane MeiselDepartment of Hematology and Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA, USA.
Mehmet Asim BilenDepartment of Hematology and Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA, USA.
David LawsonDepartment of Hematology and Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA, USA.
David CellaDepartment of Medical Social Sciences, Northwestern University, Chicago, IL, USA.
Bassel El-RayesDepartment of Hematology and Oncology, Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA, USA.
Ruth CarlosDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Emory University · USDuke University · USNorthwestern University · USUniversity of Michigan · USWake Forest University · US

Funding

ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
NCI NIH HHS P30 CA138292NCI NIH HHS UG1 CA189828
6 · The paper itself

Abstract

backgroundFinancial toxicity is commonly reported by cancer patients, but few studies have assessed caregiver perceptions. We aimed to validate the modified Comprehensive Score for Financial Toxicity (COST) in cancer caregivers, identify factors associated with financial toxicity in both patients and caregivers, and assess the association of caregiver financial toxicity with patient and caregiver outcomes.

methodsUsing a convenience sampling method, 100 dyads of adult cancer patients and a primary caregiver visiting outpatient oncology clinics (Jan-Sep 2019) were recruited. We assessed the internal consistency and convergent and divergent validity of the modified COST. Multivariable analyses identified correlates of financial toxicity. Association of financial toxicity with care non-adherence, lifestyle-altering behaviors (e.g., home refinance/sale, retirement/saving account withdrawal), and quality of life (QOL) was investigated.

resultsRecruited patient vs. caregiver characteristics were as follows: mean age: 60.6 vs. 56.5; 34% vs. 46.4% female; 79% vs. 81.4% white. The caregiver COST measure demonstrated high internal consistency (Cronbach α = 0.91). In patients, older age (B, 0.3 [95% CI, 0.1-0.4]) and higher annual household income (B, 14.3 [95% CI, 9.3-19.4]) correlated with lower financial toxicity (P < 0.05). In caregivers, lower patient financial toxicity (B, 0.4 [95% CI, 0.2-0.6]) and cancer stages 1-3 (compared to stage 4) (B, 4.6 [95% CI, 0.4-8.8]) correlated with lower financial toxicity (P < 0.05). Increased caregiver financial toxicity correlated with higher care non-adherence in patients, increased lifestyle-altering behaviors, and lower QOL in patients and caregivers (P < 0.05).

conclusionThe COST measure can also be used to assess caregiver financial toxicity. Caregivers' financial toxicity was associated with negative outcomes for both dyad members.

Indexed as

CaregiversNeoplasmsAgedFemaleFinancial StressHumansMaleMiddle AgedQuality of LifeCancerCaregiverFinancial toxicityHealth outcomes

Identifiers

PMID34255179
PMCPMC8639637
OpenAlexW3178062719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.