Evidence map›Paper›PMID 34255136›Full record

Trial reportAmino acids2021

Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women.

Flavia Giolo De Carvalho, Camila Fernanda Cunha Brandao, Vitor Rosetto Muñoz, Gabriela Batitucci, Maria Eduarda de Almeida Tavares, Giovana Rampazzo Teixeira, José Rodrigo Pauli, Leandro Pereira De Moura, Eduardo Rochete Ropelle, Dennys Esper Cintra and 4 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04279600 (Taurine Supplementation and Physical Training Effects on Adipose Tissue Mitochondrial Energy Metabolism, and Blood Inflammation and Oxidative Stress in Obese Women), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04279600 nacompletednot on this map

Taurine Supplementation and Physical Training Effects on Adipose Tissue Mitochondrial Energy Metabolism, and Blood Inflammation and Oxidative Stress in Obese Women

TypeinterventionalSponsorUniversity of Sao PauloRan2017 to 2018Enrolled24ConditionsObesityArmsTaurine, Placebo, Exercise training
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Flavia Giolo De CarvalhoSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, São Paulo, 14040-907, Brazil.
Camila Fernanda Cunha BrandaoInternal Medicine Department, Ribeirão Preto Medical School, University of São Paulo-FMRP USP, Ribeirão Preto, São Paulo, Brazil.
Vitor Rosetto MuñozLaboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, São Paulo, Brazil.
Gabriela BatitucciDepartment of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, São Paulo State University-FCFAR UNESP, Araraquara, São Paulo, Brazil.
Maria Eduarda de Almeida TavaresDepartment of Physical Education, School of Technology and Science, São Paulo State University-UNESP, Presidente Prudente, São Paulo, Brazil.
Giovana Rampazzo TeixeiraDepartment of Physical Education, School of Technology and Science, São Paulo State University-UNESP, Presidente Prudente, São Paulo, Brazil.
José Rodrigo PauliLaboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, São Paulo, Brazil.
Leandro Pereira De MouraLaboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, São Paulo, Brazil.
Eduardo Rochete RopelleLaboratory of Molecular Biology of Exercise, University of Campinas-FCA UNICAMP, Limeira, São Paulo, Brazil.
Dennys Esper CintraLaboratory of Nutritional Genomics, University of Campinas-FCA UNICAMP, Limeira, São Paulo, Brazil.
Adelino Sanchez Ramos da SilvaSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, São Paulo, 14040-907, Brazil.
Márcia Varella Morandi Junqueira-FrancoInternal Medicine Department, Ribeirão Preto Medical School, University of São Paulo-FMRP USP, Ribeirão Preto, São Paulo, Brazil.
Julio Sergio MarchiniInternal Medicine Department, Ribeirão Preto Medical School, University of São Paulo-FMRP USP, Ribeirão Preto, São Paulo, Brazil.
Ellen Cristini De FreitasSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre, Ribeirão Preto, São Paulo, 14040-907, Brazil. ellenfreitas@usp.br.ORCID http://orcid.org/0000-0002-7343-2002
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade de Ribeirão Preto · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/08036-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/10080-2
6 · The paper itself

Abstract

Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1β gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019.

Indexed as

Dietary SupplementsExerciseAdipose TissueAdipose Tissue, WhiteAdultBiomarkersBody CompositionCytokinesFemaleHumansMiddle AgedObesitySubcutaneous FatTaurineYoung AdultBiomarkersCytokinesTaurineAdipocyte plasticityAdipose tissueInflammationObesityTaurine

Identifiers

PMID34255136
OpenAlexW3179355415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.