Evidence map›Paper›PMID 34255130›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

The added value of PSMA PET/MR radiomics for prostate cancer staging.

Esteban Lucas Solari, Andrei Gafita, Sylvia Schachoff, Borjana Bogdanović, Alberto Villagrán Asiares, Thomas Amiel, Wang Hui, Isabel Rauscher, Dimitris Visvikis, Tobias Maurer and 7 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 79 citations in OpenAlex.

  1. Trial
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  5. An interpretableEuropean journal of nuclear medicine and molecular imaging · 2026
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  15. Multimodal imaging deep learning model for predicting extraprostatic extension in prostate cancer using MpMRI and 18 F-PSMA-PET/CT.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  16. The value of habitat analysis based onBMC medical imaging · 2025
    Article
  17. A Robust [Journal of imaging informatics in medicine · 2025
    Article
  18. Review
  19. Article
  20. End-to-end [Abdominal radiology (New York) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Esteban Lucas SolariSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany. elucas.solari@tum.de.ORCID http://orcid.org/0000-0001-7243-0729
Andrei GafitaSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Sylvia SchachoffSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Borjana BogdanovićSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Alberto Villagrán AsiaresSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Thomas AmielSchool of Medicine, Department of Urology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Wang HuiSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Isabel RauscherSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Dimitris VisvikisINSERM, UMR 1101, LaTIM, Univ Brest, Brest, France.
Tobias MaurerDepartment of Urology and Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Kristina SchwambornSchool of Medicine, Institute of Pathology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Mona MustafaSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Wolfgang WeberSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Nassir NavabSchool of Computer Science, Computer Aided Medical Procedures and Augmented Reality, Technical University Munich, Munich, Germany.
Matthias EiberSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Mathieu HattINSERM, UMR 1101, LaTIM, Univ Brest, Brest, France.
Stephan G NekollaSchool of Medicine, Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
TUM Klinikum · DEInserm · FRUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the performance of combined PET and multiparametric MRI (mpMRI) radiomics for the group-wise prediction of postsurgical Gleason scores (psGSs) in primary prostate cancer (PCa) patients.

methodsPatients with PCa, who underwent [

resultsAll radiomic models outperformed the baseline models. The best-performing (mean ± stdv [%]) single-modality model was the ADC model (76 ± 6%), although not significantly better (p > 0.05) than other single-modality models (T1w: 72 ± 3%, T2w: 73 ± 2%; PET: 75 ± 5%). The overall best-performing model combined PET + ADC radiomics (82 ± 5%). It significantly outperformed most other double-modality (PET + T1w: 74 ± 5%, p = 0.026; PET + T2w: 71 ± 4%, p = 0.003) and single-modality models (PET: p = 0.042; T1w: p = 0.002; T2w: p = 0.003), except the ADC-only model (p = 0.138). In this initial cohort, the PET + ADC model outperformed bGS overall (82.5% vs 72.4%) in the prediction of psGS.

conclusionAll single- and double-modality models outperformed the baseline models, showing their potential in the prediction of GS, even with an unbalanced cohort. The best-performing model included PET + ADC radiomics, suggesting a complementary value of PSMA-PET and ADC radiomics.

Indexed as

Multiparametric Magnetic Resonance ImagingProstatic NeoplasmsHumansMaleNeoplasm GradingProstatectomyRetrospective StudiesGleason scorePET/MRIProstate cancerPSMARadiomics

Identifiers

PMID34255130
PMCPMC8803696
OpenAlexW3180972814

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.