Evidence map›Paper›PMID 34254921›Full record

ArticleCurrent neuropharmacology2022

Exploring CNS Effects of American Traditional Medicines using Zebrafish Models.

Murilo S de Abreu, Fabiano Costa, Ana C V V Giacomini, Konstantin A Demin, Elena V Petersen, Denis B Rosemberg, Allan V Kalueff

Abstract read
In one paragraph

Article in Current neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Murilo S de AbreuLaboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
Fabiano CostaGraduate Program in Biological Sciences: Toxicological Biochemistry, Natural and Exact Sciences Center, Federal University of Santa Maria, Brazil.
Ana C V V GiacominiLaboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
Konstantin A DeminSchool of Pharmacy, Southwest University, Chongqing, China.
Elena V PetersenLaboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
Denis B RosembergThe International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
Allan V KalueffSchool of Pharmacy, Southwest University, Chongqing, China.

Funding

CNPq research productivity grant 305051/2018-0FAPERGS “Gaucho” Researcher Program – PQG fellowship 19/2551-0001764-2, 19/2551-0001-669-7Resource Fund of Applied Genetics MIPT 075-15-2021-684Russian Science Foundation (RSF) 20-65-46006
6 · The paper itself

Abstract

Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.

Indexed as

NeurosciencesZebrafishAnimalsDisease Models, AnimalMedicine, TraditionalNeuropharmacologyAmerican traditional medicineanimal modelsbehaviorbrain effectsdrug screeningZebrafish

Identifiers

PMID34254921
PMCPMC9608231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.