Evidence map›Paper›PMID 34254827›Full record

ArticlemSystems2021

The LysR-Type Transcriptional Regulator BsrA (PA2121) Controls Vital Metabolic Pathways in

Magdalena Modrzejewska, Adam Kawalek, Aneta Agnieszka Bartosik

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  12. Robust ParB Binding to Half-International journal of molecular sciences · 2023
    Article
  13. Article
  14. In Vitro Antibiofilm Activity of Resveratrol againstAntibiotics (Basel, Switzerland) · 2023
    Article
  15. Article
  16. MvaT binds to the PFrontiers in cellular and infection microbiology · 2023
    Article
  17. Article
  18. Article
  19. The Lrp/AsnC-Type Regulator PA2577 Controls the EamA-like Transporter GeneInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Magdalena ModrzejewskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Adam KawalekInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Aneta Agnieszka BartosikInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Institute of Biochemistry and Biophysics, Polish Academy of Sciences · PL

Funding

National Science Centre, Poland 2015/18/E/NZ2/00675
6 · The paper itself

Abstract

Pseudomonas aeruginosa, a facultative human pathogen causing nosocomial infections, has complex regulatory systems involving many transcriptional regulators. LTTR (LysR-Type Transcriptional Regulator) family proteins are involved in the regulation of various processes, including stress responses, motility, virulence, and amino acid metabolism. The aim of this study was to characterize the LysR-type protein BsrA (PA2121), previously described as a negative regulator of biofilm formation in P. aeruginosa. Genome wide identification of BsrA binding sites using chromatin immunoprecipitation and sequencing analysis revealed 765 BsrA-bound regions in the P. aeruginosa PAO1161 genome, including 367 sites in intergenic regions. The motif T-N

Indexed as

BsrA regulonLTTRLysR-type transcriptional regulatorPseudomonas aeruginosaregulatory networktricarboxylic acid cycle

Identifiers

PMID34254827
PMCPMC8407307
OpenAlexW3178936849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.