ArticlemSystems2021
A Scale-Free, Fully Connected Global Transition Network Underlies Known Microbiome Diversity.
Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Seagrasses host unique and vulnerable microbiomes, structured by inter-domain microbial interactions.iScience · 2026Article
- Coordinated Meta-Storms enables comparison of million-level microbiomes.Bioinformatics (Oxford, England) · 2025Article
- The Origin of Shared Emergent Properties in Discrete Systems.Entropy (Basel, Switzerland) · 2025Article
- Uncovering the complexity of childhood undernutrition through strain-level analysis of the gut microbiome.BMC microbiology · 2024Article
- Comprehensive Assessment of 16S rRNA Gene Amplicon Sequencing for Microbiome Profiling across Multiple Habitats.Microbiology spectrum · 2023Article
- Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection.Frontiers in microbiology · 2022Article
- Microbiome Sample Comparison and Search: From Pair-Wise Calculations to Model-Based Matching.Frontiers in microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Microbiomes are inherently linked by their structural similarity, yet the global features of such similarity are not clear. Here, we propose as a solution a search-based microbiome transition network. By traversing a composition-similarity-based network of 177,022 microbiomes, we show that although the compositions are distinct by habitat, each microbiome is on-average only seven neighbors from any other microbiome on Earth, indicating the inherent homology of microbiomes at the global scale. This network is scale-free, suggesting a high degree of stability and robustness in microbiome transition. By tracking the minimum spanning tree in this network, a global roadmap of microbiome dispersal was derived that tracks the potential paths of formulating and propagating microbiome diversity. Such search-based global microbiome networks, reconstructed within hours on just one computing node, provide a readily expanded reference for tracing the origin and evolution of existing or new microbiomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.