ArticleIntegrative zoology2022
Male heterogametic sex determination in Rana dybowskii based on sex-linked molecular markers.
Article in Integrative zoology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Identification of Male-Specific Markers by Genotyping-by-Sequencing in the Giant Spiny Frog,Genes · 2025Article
- Development and validation of sex-associated markers using whole-genome re-sequencing in frogFrontiers in genetics · 2025Article
- Genome Survey of MaleAnimals : an open access journal from MDPI · 2024Article
- Sex-linked markers in an Australian frog Platyplectrum ornatum (Limnodynastidae) with a small genome and homomorphic sex chromosomes.Scientific reports · 2022Article
- Testicular Transcriptome of Males and Pseudo-Males Provides Important New Insight into Sex Reversal ofAnimals : an open access journal from MDPI · 2022Article
- Novel genetic sex markers reveal unexpected lack of, and similar susceptibility to, sex reversal in free-living common toads in both natural and anthropogenic habitats.Molecular ecology · 2022Article
- Male heterogametic sex determination in Rana dybowskii based on sex-linked molecular markers.Integrative zoology · 2022Article
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Abstract
Identifying the mechanism for sex determination in amphibians is challenging. Very little is known about sex determination mechanisms of Rana dybowskii, a species of importance to evolutionary and conservation biology. We screened for sex-linked molecular markers in R. dybowskii in China using target region amplification polymorphism with 2 fixed primers against the sequences of Dmrt1. We found 2 male-linked molecular markers in R. dybowskii, which were 222 bp and 261 bp long. The detection rates of 222 bp marker in males form Xinglong, Huadian, and Dandong were 93.79%, 69.64%, and 13.64%, respectively, while the rate in females from Huadian was 27.50%. Besides, the detection rates of 261 bp marker in the above 3 regions were only observed in males at the rate of 93.79%, 87.50%, and 32.73%, respectively. The inheritance patterns of sex-linked molecular markers showed that the 2 sex-linked molecular markers were heterozygous. Compared to the XY-male parent, progeny from XX-pseudo-male parent possessed lower sex reversal ratio at the same rearing temperature, and the proportion of female froglets from an XX-pseudo-male parent was more than 95% at low rearing temperature (15°C). Our findings suggest that R. dybowskii displays male heterogamety, and the 2 sex-linked molecular markers may have a guiding significance for the protection and utilization of R. dybowskii.
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