Evidence map›Paper›PMID 34254733›Full record

ArticleJournal of biomedical materials research. Part A2022

Incorporating nanocrystalline cellulose into a multifunctional hydrogel for heart valve tissue engineering applications.

Nianfang Ma, Daniel Y Cheung, Jonathan T Butcher

Open access · greenAbstract read
In one paragraph

Article in Journal of biomedical materials research. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 48 citations in OpenAlex.

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  9. Cellulose-Based Nanofibers in Wound Dressing.Biomimetics (Basel, Switzerland) · 2025
    Review
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  20. Latest Advances in 3D Bioprinting of Cardiac Tissues.Advanced materials technologies · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Nianfang MaMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Daniel Y CheungMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Jonathan T ButcherMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Cornell University · US

Funding

Adhesive signaling in aortic valve development and diseaseR01HL128745 · NHLBI · CORNELL UNIVERSITY · PI BUTCHER, JONATHAN TALBOT · 2015 to 2018
$1.5M
UltraVIEW VoX spinning disk confocal for core facilityS10OD010605 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2012 to 2012
$595k
Bioprinted Vascularized Tissue ConstructsR21AR070408 · NIAMS · CORNELL UNIVERSITY · PI BUTCHER, JONATHAN TALBOT · 2016 to 2017
$399k
Howard Hughes Medical Institute 56006761NHLBI NIH HHS R01 HL128745NIAMS NIH HHS R21 AR070408NIH HHS 1S10OD010605NIH HHS NIH HL128745NIH HHS NIH R21AR070408NIH HHS S10 OD010605
6 · The paper itself

Abstract

Functional tissue engineered heart valves (TEHV) have been an elusive goal for nearly 30 years. Among the persistent challenges are the requirements for engineered valve leaflets that possess nonlinear elastic tissue biomechanical properties, support quiescent fibroblast phenotype, and resist osteogenic differentiation. Nanocellulose is an attractive tunable biological material that has not been employed to this application. In this study, we fabricated a series of photocrosslinkable composite hydrogels mNCC-MeGel (mNG) by conjugating TEMPO-modified nanocrystalline cellulose (mNCC) onto the backbone of methacrylated gelatin (MeGel). Their structures were characterized by FTIR,

Indexed as

HydrogelsOsteogenesisCell DifferentiationCelluloseHeart ValvesTissue EngineeringTissue ScaffoldsCelluloseHydrogels3D bioprintingcalcificationfibroblastic phenotypehydrogelmethacrylated gelatin (MeGel)nonlinear biomechanics

Identifiers

PMID34254733
PMCPMC9437634
OpenAlexW3177785472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.