Evidence map›Paper›PMID 34254442›Full record

ArticleEMBO molecular medicine2021

Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers.

Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, Alzheimer's Disease Neuroimaging Initiative, Philip Scheltens and 6 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 3 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. [European journal of nuclear medicine and molecular imaging · 2026
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  15. Living Alone, Early Tau Pathology, and Loneliness in Cognitively Unimpaired Older Adults During the COVID-19 Pandemic.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
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  17. APOE ɛ4 carriership determines a faster plasma p-tau217 progression in Aβ-positive individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Rik OssenkoppeleClinical Memory Research Unit, Lund University, Lund, Sweden.ORCID 0000-0003-1584-7477
Juhan ReimandAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Ruben SmithClinical Memory Research Unit, Lund University, Lund, Sweden.
Antoine LeuzyClinical Memory Research Unit, Lund University, Lund, Sweden.
Olof StrandbergClinical Memory Research Unit, Lund University, Lund, Sweden.
Sebastian PalmqvistClinical Memory Research Unit, Lund University, Lund, Sweden.ORCID 0000-0002-9267-1930
Erik StomrudClinical Memory Research Unit, Lund University, Lund, Sweden.
Henrik ZetterbergClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Alzheimer's Disease Neuroimaging Initiative
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0002-1046-6408
Jeffrey L DageEli Lilly and Company, Indianapolis, IN, USA.ORCID 0000-0002-2192-1699
Femke BouwmanAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.ORCID 0000-0002-1890-4193
Niklas Mattsson-CarlgrenClinical Memory Research Unit, Lund University, Lund, Sweden.ORCID 0000-0002-8885-7724
Shorena JanelidzeClinical Memory Research Unit, Lund University, Lund, Sweden.
Oskar HanssonClinical Memory Research Unit, Lund University, Lund, Sweden.ORCID 0000-0001-8467-7286
Lund University · SEEli Lilly (United States) · USSahlgrenska University Hospital · SEAmsterdam Neuroscience · NLTallinn University of Technology · EE

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
CIHRNIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)-related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER-2 (n = 400) and ADNI (n = 371). All had tau-PET ([

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesBiomarkersHumansPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer's diseaseCSFPETplasmatau

Identifiers

PMID34254442
PMCPMC8350902
OpenAlexW3178454960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.