Evidence map›Paper›PMID 34254382›Full record

ArticleJournal of magnetic resonance imaging : JMRI2022

Abdominal T2-Weighted Imaging and T2 Mapping Using a Variable Flip Angle Radial Turbo Spin-Echo Technique.

Mahesh B Keerthivasan, Jean-Philippe Galons, Kevin Johnson, Lavanya Umapathy, Diego R Martin, Ali Bilgin, Maria I Altbach

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mahesh B KeerthivasanDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-7841-9333
Jean-Philippe GalonsDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0003-2315-4056
Kevin JohnsonDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
Lavanya UmapathyDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
Diego R MartinDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
Ali BilginDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
Maria I AltbachDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0001-9368-2458
University of Arizona · USBanner - University Medical Center Tucson · US

Funding

Multi-Center Implementation and Validation of Efficient Magnetic Resonance Imaging and Analysis of Atherosclerotic Disease of the Cervical CarotidR01HL159200 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ALTBACH, MARIA I., DESHPANDE, VIBHAS · 2021 to 2025
$6.1M
Advancing MRI technology for early diagnosis of liver metastasesR01CA245920 · NCI · UNIVERSITY OF ARIZONA · PI ALTBACH, MARIA I., MARTIN, DIEGO R · 2020 to 2024
$2.4M
NCI NIH HHS R01 CA245920NHLBI NIH HHS R01 HL159200
6 · The paper itself

Abstract

backgroundT2 mapping is of great interest in abdominal imaging but current methods are limited by low resolution, slice coverage, motion sensitivity, or lengthy acquisitions. PURPOSE: Develop a radial turbo spin-echo technique with refocusing variable flip angles (RADTSE-VFA) for high spatiotemporal T2 mapping and efficient slice coverage within a breath-hold and compare to the constant flip angle counterpart (RADTSE-CFA). STUDY TYPE: Prospective technical efficacy. SUBJECTS: Testing performed on agarose phantoms and 12 patients. Focal liver lesion classification tested on malignant (N = 24) and benign (N = 11) lesions. FIELD STRENGTH/SEQUENCE: 1.5 T/RADTSE-VFA, RADTSE-CFA. ASSESSMENT: A constrained objective function was used to optimize the refocusing flip angles. Phantom and/or in vivo data were used to assess relative contrast, T2 estimation, specific absorption rate (SAR), and focal liver lesion classification. STATISTICAL TESTS: t-Tests or Mann-Whitney Rank Sum tests were used.

resultsPhantom data did not show significant differences in mean relative contrast (P = 0.10) and T2 accuracy (P = 0.99) between RADTSE-VFA and RADTSE-CFA. Adding noise caused T2 overestimation predominantly for RADTSE-CFA and low T2 values. In vivo results did not show significant differences in mean spleen-to-liver (P = 0.62) and kidney-to-liver (P = 0.49) relative contrast between RADTSE-VFA and RADTSE-CFA. Mean T2 values were not significantly different between the two techniques for spleen (T2 DATA

conclusionRADTSE-VFA provided noise-robust T2 estimation compared to the constant flip angle counterpart while generating T2-weighted images with comparable contrast. The VFA scheme minimized SAR improving slice efficiency for breath-hold imaging. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 1.

Indexed as

Magnetic Resonance ImagingData CollectionHumansPhantoms, ImagingProspective Studiesabdominal imagingradial MRIT2 mappingturbo spin-echovariable flip angle

Identifiers

PMID34254382
PMCPMC8678192
OpenAlexW3179656664

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.