ArticleInfection2021
Influence of microbiological diagnosis on the clinical course of spondylodiscitis.
Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Recommendations of the International Consensus Meeting (ICM) 2025 on Spinal Infections: Part A Pyogenic Spondylodiscitis.Global spine journal · 2026Article
- The Incidence, Pathogen Spectrum, and Resistance Profile of Pyogenic Spondylodiscitis: A Nationwide Retrospective Evaluation of G-DRG Data.Deutsches Arzteblatt international · 2026Observational
- Metagenomic next-generation sequencing for the diagnosis of suspected spinal infections from biopsy samples: a novel biopsy toolkit design and real-life diagnostic value.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Spinal infections.Frontiers in neuroscience · 2026Review
- Etiologic spectrum and diagnostic gaps of spinal infections: a cross-sectional study in Qingdao, China.Preventive medicine reports · 2026Article
- ElastoMeric Infusion Pumps for Hospital AntibioTICs (EMPHATIC): A Feasibility Study.Antibiotics (Basel, Switzerland) · 2025Article
- Clinical application value of nanopore-targeted sequencing technology for primary spine infection: a mulicenter, retrospective observational study.BMC infectious diseases · 2025Observational
- Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis.Infection · 2025Article
- Segmentation-based 3D volumetry and linear regression modeling for assessing the vertebral bone loss in pyogenic vertebral osteomyelitis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Cervical Pyogenic Spondylitis: A Comprehensive Review of Diagnosis and Treatment Strategy.Journal of clinical medicine · 2025Review
- The Impact of Location on De Novo Spondylodiscitis: Regions Matter but Are Secondary to Comorbidities.Journal of clinical medicine · 2025Article
- Gram-negative rods are associated with prolonged treatment in patients with thoracolumbar pyogenic spondylitis after minimally invasive posterior fixation compared with gram-positive cocci: a multicenter retrospective cohort study.BMC musculoskeletal disorders · 2025Article
- Current knowledge of vertebral osteomyelitis: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- Article
- Cervical spine infection arising from chronic paronychia: A case report and review of literature.World journal of orthopedics · 2024Article
- Spondylodiscitis and Its Mimickers: A Pictorial Review.Biomedicines · 2024Review
- Removal of infected bone in-growth pelvic fixation implants and microcomputed tomography analysis of osseous integration: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection.Acta orthopaedica et traumatologica turcica · 2024Article
- The importance of the bacterial spectrum in the clinical diagnostics and management of patients with spontaneous pyogenic spondylodiscitis and isolated spinal epidural empyema: a 20-year cohort study at a single spine center.BMC infectious diseases · 2024Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study sought to recognize differences in clinical disease manifestations of spondylodiscitis depending on the causative bacterial species.
methodsWe performed an evaluation of all spondylodiscitis cases in our clinic from 2013-2018. 211 patients were included, in whom a causative bacterial pathogen was identified in 80.6% (170/211). We collected the following data; disease complications, comorbidities, laboratory parameters, abscess occurrence, localization of the infection (cervical, thoracic, lumbar, disseminated), length of hospital stay and 30-day mortality rates depending on the causative bacterial species. Differences between bacterial detection in blood culture and intraoperative samples were also recorded.
resultsThe detection rate of bacterial pathogens through intraoperative sampling was 66.3% and could be increased by the results of the blood cultures to a total of 80.6% (n = 170/211). S. aureus was the most frequently detected pathogen in blood culture and intraoperative specimens and and was isolated in a higher percentage cervically than in other locations of the spine. Bacteremic S. aureus infections were associated with an increased mortality (31.4% vs. overall mortality of 13.7%, p = 0.001), more frequently developing complications, such as shock, pneumonia, and myocardial infarction. Comorbidities, abscesses, length of stay, sex, and laboratory parameters all showed no differences depending on the bacterial species.
conclusionBlood culture significantly improved the diagnostic yield, thus underscoring the need for a structured diagnostic approach. MSSA spondylodiscitis was associated with increased mortality and a higher incidence of complications.
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