ArticleSchizophrenia bulletin2021
A Diagnosis and Biotype Comparison Across the Psychosis Spectrum: Investigating Volume and Shape Amygdala-Hippocampal Differences from the B-SNIP Study.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Combining neuroimaging and brain stimulation to test alternative causal pathways for nicotine addiction in schizophrenia.Brain stimulationTrial
- Identification of distinct clinical phenotypes and their neurobiological signatures in stress-exposed individuals: A multimodal machine learning approach.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Volume and Tempo: Cortical Excitability and Trial-to-Trial Consistency of Auditory Responses Distinguish Psychosis Biotypes.Research square · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Subtyping schizophrenia via machine learning by using structural neuroimaging.Translational psychiatry · 2025Review
- Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes.Translational psychiatry · 2025Article
- Moving toward precision and personalized treatment strategies in psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Gaze behaviors during free viewing revealed differences in visual salience processing across four major psychiatric disorders: a mega-analysis study of 1012 individuals.Molecular psychiatry · 2025Article
- Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations.Journal of clinical medicine · 2024Review
- Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes.Advances in neurobiology · 2024Review
- The Modern Concept of Schizoaffective Disorder: A Narrative Review.Consortium psychiatricum · 2024Review
- Clinical characterization and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT)-1.Schizophrenia research · 2023Article
- Emotional scene processing in biotypes of psychosis.Psychiatry research · 2023Article
- Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia.Biological psychiatry · 2022Article
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.Schizophrenia bulletin · 2022Article
- Longitudinal changes of deep gray matter shape in multiple sclerosis.NeuroImage. Clinical · 2022Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveBrain-based Biotypes for psychotic disorders have been developed as part of the B-SNIP consortium to create neurobiologically distinct subgroups within idiopathic psychosis, independent from traditional phenomenological diagnostic methods. In the current study, we aimed to validate the Biotype model by assessing differences in volume and shape of the amygdala and hippocampus contrasting traditional clinical diagnoses with Biotype classification.
methodsA total of 811 participants from 6 sites were included: probands with schizophrenia (n = 199), schizoaffective disorder (n = 122), psychotic bipolar disorder with psychosis (n = 160), and healthy controls (n = 330). Biotype classification, previously developed using cognitive and electrophysiological data and K-means clustering, was used to categorize psychosis probands into 3 Biotypes, with Biotype-1 (B-1) showing reduced neural salience and severe cognitive impairment. MAGeT-Brain segmentation was used to determine amygdala and hippocampal volumetric data and shape deformations.
resultsWhen using Biotype classification, B-1 showed the strongest reductions in amygdala-hippocampal volume and the most widespread shape abnormalities. Using clinical diagnosis, probands with schizophrenia and schizoaffective disorder showed the most significant reductions of amygdala and hippocampal volumes and the most abnormal hippocampal shape compared with healthy controls. Biotype classification provided the strongest neuroanatomical differences compared with conventional DSM diagnoses, with the best discrimination seen using bilateral amygdala and right hippocampal volumes in B-1.
conclusionThese findings characterize amygdala and hippocampal volumetric and shape abnormalities across the psychosis spectrum. Grouping individuals by Biotype showed greater between-group discrimination, suggesting a promising approach and a favorable target for characterizing biological heterogeneity across the psychosis spectrum.
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