Evidence map›Paper›PMID 34254032›Full record

ArticleFuture science OA2021

A machine learning PROGRAM to identify COVID-19 and other diseases from hematology data.

Patrick A Gladding, Zina Ayar, Kevin Smith, Prashant Patel, Julia Pearce, Shalini Puwakdandawa, Dianne Tarrant, Jon Atkinson, Elizabeth McChlery, Merit Hanna and 10 more

Abstract read
In one paragraph

Article in Future science OA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Patrick A GladdingDepartment of Cardiology, Waitematā District Health Board, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-0380-3592
Zina AyarClinical Information Services, Waitematā District Health Board, Auckland, New Zealand.
Kevin SmithClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Prashant PatelClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Julia PearceClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Shalini PuwakdandawaClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Dianne TarrantClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Jon AtkinsonClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Elizabeth McChleryClinical laboratory, Waitematā District Health Board, Auckland, New Zealand.
Merit HannaDepartment of Hematology, Waitematā District Health Board, Auckland, New Zealand.
Nick GowDepartment of Infectious diseases, Waitematā District Health Board, Auckland, New Zealand.
Hasan BhallyDepartment of Infectious diseases, Waitematā District Health Board, Auckland, New Zealand.
Kerry ReadDepartment of Infectious diseases, Waitematā District Health Board, Auckland, New Zealand.
Prageeth JayathissaInstitute for Innovation & Improvement (i3), Waitematā District Health Board, Auckland, New Zealand.
Jonathan WallaceInstitute for Innovation & Improvement (i3), Waitematā District Health Board, Auckland, New Zealand.
Sam NortonNanix Ltd, Dunedin, New Zealand.
Nick KasabovKnowledge Engineering & Discovery Research Institute (KEDRI), Auckland University of Technology, Auckland, New Zealand.
Cristian S CaludeSchool of Computer Science, University of Auckland, Auckland, New Zealand.
Deborah SteelSysmex New Zealand Ltd, Auckland, New Zealand.
Colin MckenzieSysmex New Zealand Ltd, Auckland, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe propose a method for screening full blood count metadata for evidence of communicable and noncommunicable diseases using machine learning (ML). MATERIALS &

methodsHigh dimensional hematology metadata was extracted over an 11-month period from Sysmex hematology analyzers from 43,761 patients. Predictive models for age, sex and individuality were developed to demonstrate the personalized nature of hematology data. Both numeric and raw flow cytometry data were used for both supervised and unsupervised ML to predict the presence of pneumonia, urinary tract infection and COVID-19. Heart failure was used as an objective to prove method generalizability.

resultsChronological age was predicted by a deep neural network with R

conclusionML applied to hematology data could predict communicable and noncommunicable diseases, both at local and global levels.

Indexed as

biological ageCOVID-19full blood countheart failurehematologymachine learningpneumonia

Identifiers

PMID34254032
PMCPMC8204819

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.