Evidence map›Paper›PMID 34254031›Full record

ReviewFuture science OA2021

Mortality rate and biomarker expression within COVID-19 patients who develop acute ischemic stroke: a systematic review and meta-analysis.

Ahmed Yassin, Ansam Ghzawi, Abdel-Hameed Al-Mistarehi, Khalid El-Salem, Amira Y Benmelouka, Ahmed M Sherif, Nesrine BenhadjDahman, Nameer AlAdamat, Amine Jemel, Ahmed Negida and 1 more

Abstract readReview
In one paragraph

Review in Future science OA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  10. COVID19 biomarkers: What did we learn from systematic reviews?Frontiers in cellular and infection microbiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ahmed YassinDivision of Neurology, Department of Neurosciences, Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan.ORCID https://orcid.org/0000-0002-3175-0408
Ansam GhzawiFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Abdel-Hameed Al-MistarehiDepartment of Public Health & Family Medicine, Jordan University of Science & Technology, Irbid, Jordan.
Khalid El-SalemDivision of Neurology, Department of Neurosciences, Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan.
Amira Y BenmeloukaUniversity of Algiers, Algeria.
Ahmed M SherifFaculty of Human Medicine, Zagazig University, Sharkia, Egypt.
Nesrine BenhadjDahmanFaculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
Nameer AlAdamatDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan.
Amine JemelDepartment of Thoracic & Cardiovascular Surgery, Abderrahmen Mami Hospital, Tunisia.
Ahmed NegidaFaculty of Human Medicine, Zagazig University, Sharkia, Egypt.
Mohamed AbdelmonemFaculty of Medicine, Fayoum University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the mortality difference between acute ischemic stroke (AIS) and non-AIS groups within COVID-19 patients. MATERIALS &

methodsWe included observational studies through September 2020 that categorized COVID-19 patients into two groups (with and without AIS).

resultsEight studies with a total sample size of 19,399 COVID-19 patients were included. The pooled risk difference showed that patients with COVID-19 who developed AIS had significantly higher mortality than those without AIS by a risk difference of 24% (95% CI: 0.10-0.39; p = 0.001). In two studies, the COVID-19+AIS group had significantly higher lymphocytes, procalcitonin and creatinine levels.

conclusionDeveloping AIS significantly adds to the mortality of COVID-19. Timely interventions to manage those patients are strongly recommended.

Indexed as

biomarkerscoronavirusCOVID-19ischemic strokemortality ratestroke

Identifiers

PMID34254031
PMCPMC8114837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.