ArticleNature cell biology2021
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
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Article in Nature cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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77citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
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Who cites it
77 citing papers in PubMed, 104 citations in OpenAlex.
- Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.eLife · 2026Article
- tRNA methylation: functional insights and epitranscriptomic regulation.Cell communication and signaling : CCS · 2026Review
- Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting mScience advances · 2026Article
- RNA methylation in cell death: mechanisms and clinical applications.Molecular cancer · 2026Review
- Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples.Nature biotechnology · 2026Article
- Interplay of RNA mFASEB bioAdvances · 2026Article
- m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2026Article
- The RNA methylation modification as an immunometabolic regulatory hub in pancreatic cancer: from mechanistic insights to clinical translation perspectives.Molecular cancer · 2026Review
- mCell death & disease · 2026Article
- Unravelling Multilayered RNA Modification Networks in Female Reproduction and Obstetric/Gynaecologic Disorders.Biomolecules · 2026Review
- tRNA modifications in cancer: from molecular mechanisms to clinical translation.Biomarker research · 2026Review
- Regulation of RNA-binding proteins by small biomolecules.Nature reviews. Molecular cell biology · 2026Review
- Identification of Novel Alternative Transcripts of the Human ALKBH Gene Family and Investigation of Their Unique Expression Signatures in Cancer Cells.Current issues in molecular biology · 2026Article
- Hidden in plain sight: illuminating the tRNA landscape by sequencing.Genome biology · 2026Review
- hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination.Nature communications · 2026Article
- Reversing enhancer RNA-mediated IKBKE gene repression enables synthetic anticancer immunity in prostate cancer models.The Journal of clinical investigation · 2026Article
- RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026Review
- The Rare RNA Methylations m²G, Cm, m⁵U and ms²i⁶A: Roles in Disease Pathogenesis and Emerging Therapeutic Implications.International journal of medical sciences · 2026Review
- Association of genetic variants in mBMC cancer · 2025Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 5 institutions in 3 countries.
Li-Sheng ZhangDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Qing-Ping XiongState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, PR China.
Sonia Peña PerezDepartment of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Chang LiuDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Jiangbo WeiDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2691-6490
Cassy LeDepartment of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Linda ZhangDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Bryan T HaradaDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9683-782X
Qing DaiDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8578-1568
Xinran FengDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Ziyang HaoDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Yuru WangDepartment of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Xueyang DongDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2186-1726
Lulu HuDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
En-Duo WangState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, PR China.
Tao PanDepartment of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.
Arne KlunglandDepartment of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.ORCID http://orcid.org/0000-0001-7274-3661
Ru-Juan LiuState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, PR China. liurj@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0001-7459-3126
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.ORCID http://orcid.org/0000-0003-4319-7424
Howard Hughes Medical Institute · USOslo University Hospital · NOShanghaiTech University · CNUniversity of Chicago · USCenter for Excellence in Molecular Cell Science · CN
Funding
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MDirect Oxidative Nucleic Acids DemethylationR01ES030546 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2019 to 2023
$1.9MNHGRI NIH HHS RM1 HG008935NIEHS NIH HHS R01 ES030546
Abstract
Members of the mammalian AlkB family are known to mediate nucleic acid demethylation
Indexed as
RNA Processing, Post-TranscriptionalAdenosineAlkB EnzymesCytidineGuanosineHEK293 CellsHeLa CellsHep G2 CellsHumansMitochondriaMitochondrial ProteinsProtein BiosynthesisRNA, MitochondrialRNA, Transfer1-methyladenosine1-methylguanosine3-methylcytidineAdenosineAlkB EnzymesALKBH7 protein, humanCytidineGuanosineMitochondrial ProteinsN(2),N(2)-dimethylguanosineRNA, MitochondrialRNA, Transfer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.