Evidence map›Paper›PMID 34253885›Full record

ArticleThe Journal of antibiotics2021

The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation.

Neveen Madbouly, Ayman Azmy, Abeer Salama, Azza El-Amir

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Synergistic effect of arginine andIranian journal of basic medical sciences · 2023
    Article
  2. Article
  3. Article
  4. Antioxidative and Anti-Inflammatory Protective Effects ofOxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Neveen MadboulyZoology Department, Faculty of Science, Cairo University, Cairo, Egypt. aneveen@sci.cu.edu.eg.
Ayman AzmyZoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
Abeer SalamaPharmacology Department, National Research Centre, Cairo, Egypt.
Azza El-AmirZoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
Cairo University · EGNational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amikacin (AMK) is one of the most effective aminoglycoside antibiotics. However, nephrotoxicity is a major deleterious and dose-limiting side effect associated with its clinical use especially in high dose AMK-treated patients. The present study assessed the ability of taurine (TAU) to alleviate or prevent AMK-induced nephrotoxicity if co-administrated with AMK focusing on inflammation, apoptosis, and fibrosis. Male Sprague Dawley rats were assigned to six equal groups. Group 1: rats received saline (normal control), group 2: normal rats received 50 mg kg

Indexed as

AmikacinAnimalsAnti-Bacterial AgentsApoptosisBlood Urea NitrogenCreatinineDose-Response Relationship, DrugFibrosisHSP27 Heat-Shock ProteinsInflammationKidney DiseasesMaleMonocytesRatsRats, Sprague-DawleyTaurineAmikacinAnti-Bacterial AgentsCreatinineHSP27 Heat-Shock ProteinsHspb1 protein, ratTaurineTlr4 protein, ratToll-Like Receptor 4Uric Acid

Identifiers

PMID34253885
OpenAlexW3181715253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.