ArticleThe Journal of antibiotics2021
Alternariasin A, new pentacyclic cytochalasin from the fungus Alternaria alternate.
Article in The Journal of antibiotics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cytochalasins are a fascinating class of natural compounds: advances in the chemistry, biological activities, mode of action, and structure-activity relationships of novel cytochalasins isolated in the last decade are described.Natural products and bioprospecting · 2026Review
- Sulfoxide-Containing Bisabolane Sesquiterpenoids with Antimicrobial and Nematicidal Activities from the Marine-Derived FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Cloning and Functional Characterization of the Polyketide Synthases Based on Genome Mining ofFrontiers in microbiology · 2022Article
- Bioactive PKS-NRPS Alkaloids from the Plant-Derived Endophytic FungusMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternariasin A (1), one new cytochalasin possessing the benzo[4,5]indeno[2,1-d]isoindole-1,3,13(2H,3aH)-trione skeleton, and five known compounds 2-6 were isolated from the solid cultures of the Midui Glacier-derived fungus Alternaria alternata. Their structures were elucidated by NMR and MS spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 displayed antibacterial activity against the S. aureus, B. subtilis and E. coli with MIC values of 16.7, 16.7 and 33.3 μΜ, respectively. While compound 3 showed potent cytotoxicity against a small panel of human tumour cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.