ArticleInternational journal of obesity (2005)2021
Cord blood metabolic signatures predictive of childhood overweight and rapid growth.
Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Exploring Metabolic Signatures: Unraveling the Association with Obesity in Children and Adolescents.Nutrients · 2025Pooled it
- A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children.Clinical epigenetics · 2025Pooled it
- Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.BMC medicine · 2023Pooled it
- Serum metabolic signatures of nutritional status in early childhood: results from the Brazilian National Survey on Child Nutrition (ENANI-2019).European journal of nutrition · 2026Article
- Early pregnancy metabolomic signatures for child growth trajectories: a prospective metabolome-wide association study.The American journal of clinical nutrition · 2026Article
- Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up.mSystems · 2026Article
- Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome.Journal of the Endocrine Society · 2026Article
- Cord serum metabolic signatures associated with neonatal anthropometry and neurodevelopment through age two in twins.iScience · 2026Article
- Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort.JAMA network open · 2025Article
- The Impact of Maternal Supplementation of Fish Oil and/or Probiotics During Pregnancy on the Serum Metabolomic Profile From Infancy to Childhood: Secondary Analysis of a Randomized Placebo-Controlled Trial.Current developments in nutrition · 2025Article
- Microbiome Research in Greece: A Comprehensive Bibliometric Study.Microorganisms · 2025Article
- Metabolomic profiles during early childhood and risk of food allergies and asthma in multiethnic children from a prospective birth cohort.The Journal of allergy and clinical immunology · 2024Article
- Cord Blood Proteomic Profiles, Birth Weight, and Early Life Growth Trajectories.JAMA network open · 2024Article
- Article
- The Associations of Maternal Health Characteristics, Newborn Metabolite Concentrations, and Child Body Mass Index among US Children in the ECHO Program.Metabolites · 2023Article
- Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity.Frontiers in endocrinology · 2023Article
- Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.International journal of obesity (2005) · 2022Article
- Probiotics synergized with conventional regimen in managing Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Integration of proteomic and metabolomic analyses: New insights for mapping informal workers exposed to potentially toxic elements.Frontiers in public health · 2022Article
- Cord blood metabolic signatures predictive of childhood overweight and rapid growth.International journal of obesity (2005) · 2021Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 7 countries.
Funding
Abstract
introductionMetabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy and overweight in early childhood in four European birth cohorts.
methodsUntargeted liquid chromatography-mass spectrometry metabolomic profiles were measured in cord blood from 399 newborns from four European cohorts (ENVIRONAGE, Rhea, INMA and Piccolipiu). Rapid growth in the first year of life and overweight in childhood was defined with reference to WHO growth charts. Metabolome-wide association scans for rapid growth and overweight on over 4500 metabolic features were performed using multiple adjusted logistic mixed-effect models and controlling the false discovery rate (FDR) at 5%. In addition, we performed a look-up analysis of 43 pre-annotated metabolites, previously associated with birthweight or rapid growth.
resultsIn the Metabolome-Wide Association Study analysis, we identified three and eight metabolites associated with rapid growth and overweight, respectively, after FDR correction. Higher levels of cholestenone, a cholesterol derivative produced by microbial catabolism, were predictive of rapid growth (p = 1.6 × 10
conclusionThe metabolites identified here may assist in the identification of children at risk of developing obesity and improve understanding of mechanisms involved in postnatal growth. Cholestenone and BCAAs are suggestive of a role of the gut microbiome and nutrient signalling respectively in child growth trajectories.
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