ArticleScientific reports2021
Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Omission of Axillary Surgery in Patients with Invasive Lobular Carcinoma of the Breast: Rates of Nodal Involvement in Clinically Node Negative Patients and Impact on Recurrence in a Single Institution Analysis.Annals of surgical oncology · 2026Article
- Age-Associated Four-Gene Prognostic Signature in Breast Cancer.Cancer reports (Hoboken, N.J.) · 2026Article
- Physiologically-Based Pharmacokinetics of Ribociclib Drug-Drug Interactions and Organ Impairment Pharmacokinetics in Early Breast Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Age-stratified analysis of invasive lobular carcinoma reveals comparable clinicopathological and molecular features across age groups.Discover oncology · 2026Article
- Construction of a prediction model for axillary lymph node metastasis in stage cN0 hormone receptor-positive breast cancer: based on interpretable machine learning methods.Frontiers in oncology · 2026Article
- The incidence, clinicopathological characteristics and the survival outcomes among young breast cancer patients in Alexandria, Egypt.Ecancermedicalscience · 2026Article
- Multiparametric MRI-based radiomics of whole-tumor and habitat regions for predicting HER2 status in young breast cancer: a two-center study.Frontiers in oncology · 2026Article
- Strategies to enhance management of HER2-positive breast cancer in the elderly: an expert consensus perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Article
- HER2/neu 655 polymorphism, trastuzumab-induced cardiotoxicity, and survival in HER2-positive breast cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- A nomogram model for predicting the risk of axillary lymph node metastasis in patients with early breast cancer and cN0 status.Oncology letters · 2024Article
- Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors.Journal of cancer research and clinical oncology · 2023Article
- Clinicopathological Features of Invasive Breast Cancer: A Five-Year Retrospective Study in Southern and South-Western Ethiopia.Medicines (Basel, Switzerland) · 2023Article
- Clinical features and prognostic factors of breast cancer in young women: a retrospective single-center study.Archives of gynecology and obstetrics · 2023Article
- Age has a U-shaped relationship with breast cancer outcomes in women: a cohort study.Frontiers in oncology · 2023Article
- Geriatric assessment for older patients with breast cancer: A single-institution study.Frontiers in oncology · 2023Article
- Young Filipino breast cancer patients have worse survival outcomes.Ecancermedicalscience · 2023Article
- Effect of adjuvant chemotherapy on the survival outcomes of elderly breast cancer: A retrospective cohort study based on SEER database.Journal of evidence-based medicine · 2022Article
- Ultrasonography and clinicopathological features of breast cancer in predicting axillary lymph node metastases.BMC cancer · 2022Article
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8 authors.
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Abstract
In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417). Statistical models were used to investigate the associations between age groups, clinical characteristics and treatment outcomes. Compared to younger patients, older patients were more likely to present with advanced-stage disease (20.6% vs. 15.1%, p = .028). However, among those with non-metastatic disease, younger patients tended to have more aggressive pathological features, including positive axillary lymph nodes (73.2% vs. 55.6%, p < .001), T-3/4 (28.2% vs. 13.8%, p < .001) and HER2-positive disease (29.3% vs. 16.3%, p < .001). The 5-year overall survival (OS) rate was significantly better for the younger (72.1%) compared to the older (67.6%), p = .035. However, no significant difference was observed in disease-free survival (DFS) between the two groups.In conclusion, younger patients with breast cancer present with worse clinical and pathological features, albeit a better OS rate. The difference in DFS between the two groups was not insignificant, suggesting that older women were more likely to die from non-cancer related causes.
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