ArticleScientific reports2021
Influence of heart rate correction formulas on QTc interval stability.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ovulatory and anovulatory cycle phase influences on QT interval dynamics during the menstrual cycle.PloS one · 2025Pooled it
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Exposure-safety analysis of QTc interval and transaminase levels following bedaquiline administration in patients with drug-resistant tuberculosis.CPT: pharmacometrics & systems pharmacology · 2021Trial
- Commentary on the Predictive Value of P-Wave Dispersion and QTc Dispersion in Preeclampsia.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- From Empirical to More Precise Correction: Multidimensional Performance Evaluation of QTc Formulas in a Cohort of Healthy Asian Youth.Journal of the American Heart Association · 2026Article
- Prevalence of electrocardiographic abnormalities and predictors of QTc prolongation in patients with diabetic ketoacidosis: A retrospective cohort study.SAGE open medicine · 2026Article
- Intra-subject covariates of QT variability indices: influence of ECG noise.Frontiers in physiology · 2026Article
- Dilemma of Finding the Most Useful QTc Formula: A Retrospective Analysis of South-East London.Cureus · 2025Article
- Electrocardiographic Abnormalities in Elderly Patients Receiving Psychotropic Therapy in the Emergency Department: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2025Article
- Sodium Alginate Hydrogel Infusion of Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles and p38α Antagonistic Peptides in Myocardial Infarction Fibrosis Mitigation.Journal of the American Heart Association · 2025Article
- Transient ischemic attack and acute ischemic stroke: evidence of altered corrected index of cardiac electrophysiological balance.Frontiers in neurology · 2025Article
- Single intravenous dose ondansetron induces QT prolongation in adult emergency department patients: a prospective observational study.International journal of emergency medicine · 2024Article
- Relationship between Alzheimer dementia and QT interval: A meta-analysis.Aging medicine (Milton (N.S.W)) · 2024Review
- Electrophysiological Characterization of Subclinical and Overt Hypertrophic Cardiomyopathy by Magnetic Resonance Imaging-Guided Electrocardiography.Journal of the American College of Cardiology · 2024Article
- The optimal QTc selection in patients of acute myocardial infarction with poor perioperative prognosis.BMC cardiovascular disorders · 2023Article
- Cardiac Electromechanical Activity in Healthy Cats and Cats with Cardiomyopathies.Sensors (Basel, Switzerland) · 2023Article
- Correcting bias in cardiac geometries derived from multimodal images using spatiotemporal mapping.Scientific reports · 2023Article
- Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.Clinical and translational science · 2023Article
- Accurate QT correction method from transfer entropy.Cardiovascular digital health journal · 2023Article
- An efficient edge/cloud medical system for rapid detection of level of consciousness in emergency medicine based on explainable machine learning models.Neural computing & applications · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate corrections (Bazett, Fridericia, Dmitrienko, Framingham, Schlamowitz, Hodges, Ashman, Rautaharju, Sarma, and Rabkin) were applied to 452,440 ECG measurements made in 539 healthy volunteers (259 females, mean age 33.3 ± 8.4 years). For each correction formula, the short term (5-min time-points) and long-term (day-time hours) variability of rate corrected QT values (QTc) was investigated together with the comparisons of the QTc values with individually corrected QTcI values obtained by subject-specific modelling of the QT/RR relationship and hysteresis. The results showed that (a) both in terms of short-term and long-term QTc variability, Bazett correction led to QTc values that were more variable than the results of other corrections (p < 0.00001 for all), (b) the QTc variability by Fridericia and Framingham corrections were not systematically different from each other but were lower than the results of other corrections (p-value between 0.033 and < 0.00001), and (c) on average, Bazett QTc values departed from QTcI intervals more than the QTc values of other corrections. The study concludes that (a) previous suggestions that Bazett correction should no longer be used in clinical practice are fully justified, (b) replacing Bazett correction with Fridericia and/or Framingham corrections would improve clinical QTc monitoring, (c) heart rate stability is needed for valid QTc assessment, and (d) development of further QTc corrections for day-to-day use is not warranted.
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