Evidence map›Paper›PMID 34253690›Full record

ArticleAging2021

The dual distinct role of telomerase in repression of senescence and myofibroblast differentiation.

Masanori Harada, Biao Hu, Jeffrey Lu, Jing Wang, Andrew E Rinke, Zhe Wu, Tianju Liu, Sem H Phan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

Masanori HaradaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Biao HuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jeffrey LuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jing WangDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Andrew E RinkeDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Zhe WuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Tianju LiuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sem H PhanDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · US

Funding

BM alterations in exacerbation of pulmonary fibrosisR01HL138417 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PHAN, SEM H · 2018 to 2021
$2.3M
Resistin-like molecules in pulmonary fibrosisR01HL112880 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PHAN, SEM H · 2013 to 2016
$2.0M
NHLBI NIH HHS R01 HL112880NHLBI NIH HHS R01 HL138417
6 · The paper itself

Abstract

Many aging related diseases such as cancer implicate the myofibroblast in disease progression. Furthermore genesis of the myofibroblast is associated with manifestation of cellular senescence of unclear significance. In this study we investigated the role of a common regulator, namely telomerase reverse transcriptase (TERT), in order to evaluate the potential significance of this association between both processes. We analyzed the effects of TERT overexpression or deficiency on expression of

Indexed as

ActinsCell DifferentiationCellular SenescenceCyclin-Dependent Kinase Inhibitor p16HumansMaleMyofibroblastsPromoter Regions, GeneticRNA, Small InterferingTelomeraseACTA2 protein, humanActinsCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16RNA, Small InterferingTelomeraseTERT protein, humancellular senescencemyofibroblasttelomerase

Identifiers

PMID34253690
PMCPMC8312426
OpenAlexW3196547213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.