Trial reportBMJ open2021
Clinical effects of high-intensity laser therapy on patients with chronic refractory wounds: a randomised controlled trial.
Trial report in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The importance of power in photobiomodulation: a systematic review and meta-analysis of high-intensity laser therapy.Frontiers in integrative neuroscience · 2026Pooled it
- Effectiveness of electrophysical agents for treating pressure injuries: a systematic review.Lasers in medical science · 2022Pooled it
- Effectiveness of High Power Laser Therapy on Pain and Isokinetic Peak Torque in Athletes with Proximal Hamstring Tendinopathy: A Randomized Trial.BioMed research international · 2022Trial
- Comparative Efficacy and Safety of Electrical Stimulation Therapies for Diabetic Ulcers: A Network Meta-analysis of Randomized Controlled Trials.Advances in therapy · 2025Article
- Review
- The Role of the Six-Minute Walk Test in the Functional Evaluation of the Efficacy of Rehabilitation Programs After COVID-19.Life (Basel, Switzerland) · 2024Article
- The Effectiveness of High Intensity Laser in Improving Motor Deficits in Patients with Lumbar Disc Herniation.Life (Basel, Switzerland) · 2024Article
- The efficacy of high-intensity laser therapy in wound healing: a narrative review.Lasers in medical science · 2024Review
- Accelerating Healing and Relieving Pain: High-Intensity Laser Therapy for Paraneoplastic Cutaneous Vasculitis Associated with Multiple Myeloma.The American journal of case reports · 2024Article
- High-Intensity Laser Therapy - An Option for Managing the Pain in Anal Fissures.Journal of lasers in medical sciences · 2024Article
- [Construction of the burn rehabilitation system].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Application of double-tube negative pressure drainage in repair of refractory wounds.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Evaluation of injectable platelet-rich fibrin produced by a simple twice-centrifugation method combined with vacuum sealing drainage technology in the treatment of chronic refractory wounds.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effectiveness of high-intensity laser therapy (HILT) on chronic refractory wounds.
settingThe outpatient wound care department of the Affiliated Jiangsu Shengze Hospital of Nanjing Medical University from August 2019 to June 2020.
participantsSixty patients were enrolled in this study and were randomised into control (n=30) and treatment (n=30) groups. INTERVENTIONS AND OUTCOME MEASURES: The control group was treated only with conventional wound dressing, whereas the treatment group received irradiation with HILT in addition to standard wound care, such as debridement, wound irrigation with normal saline solution and application of dressing and sterile gauze. Patient scores on the Bates-Jensen Wound Assessment Tool (BWAT) and Pressure Ulcer Scale for Healing (PUSH) were evaluated before and after 1, 2 and 3 weeks of treatment.
resultsOne patient was excluded from the control group, and a total of 59 subjects completed the trial. The BWAT scores significantly decreased in the treatment group compared with the control group at the end of 3-week treatment (difference=-3.6; 95% CI -6.3 to-0.8; p<0.01). Similarly, patients in treatment group showed a significant reduction of PUSH scores compared with the control group (difference=-5.3; 95% CI -8.1 to -2.6; p<0.01).
conclusionsThe therapeutic effects of HILT on chronic refractory wounds are significant and far more superior to those of conventional wound dressing. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Registry; ChiCTR1900023157. URL: http://www.chictr.org.cn/showproj.aspx?proj=38866.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.