ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Hippocampal Sequencing Mechanisms Are Disrupted in a Maternal Immune Activation Model of Schizophrenia Risk.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Review
- The role of prefrontal-hippocampal functional connectivity in schizophrenia-related cognitive dysfunction and the thalamic ventral midline involvement:Frontiers in neuroscience · 2025Review
- Beyond TORCH: A narrative review of the impact of antenatal and perinatal infections on the risk of disability.Neuroscience and biobehavioral reviews · 2023Review
- Hippocampal phase precession is preserved under ketamine, but the range of precession across a theta cycle is reduced.Journal of psychopharmacology (Oxford, England) · 2023Article
- Aberrant Phase Precession of Lateral Septal Cells in a Maternal Immune Activation Model of Schizophrenia Risk May Disrupt the Integration of Location with Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Disorganization of Oscillatory Activity in Animal Models of Schizophrenia.Frontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Episodic memory requires information to be stored and recalled in sequential order, and these processes are disrupted in schizophrenia. Hippocampal phase precession and theta sequences are thought to provide a biological mechanism for sequential ordering of experience at timescales suitable for plasticity. These phenomena have not previously been examined in any models of schizophrenia risk. Here, we examine these phenomena in a maternal immune activation (MIA) rodent model. We show that while individual pyramidal cells in the CA1 region continue to precess normally in MIA animals, the starting phase of precession as an animal enters a new place field is considerably more variable in MIA animals than in controls. A critical consequence of this change is a disorganization of the ordered representation of experience via theta sequences. These results provide the first evidence of a biological-level mechanism that, if it occurs in schizophrenia, may explain aspects of disorganized sequential processing that contribute to the cognitive symptoms of the disorder.
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Registered trials
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