ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Dopamine Axons in Dorsal Striatum Encode Contralateral Visual Stimuli and Choices.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Region-specific weighting of sensory intensity and reward prediction error by dopamine signals.iScience · 2026Article
- Aberrant Functional Lateralization and Interhemispheric Synergy in High Myopia: Insights From Neurotransmitter Distribution Signatures and Machine Learning Classification.Investigative ophthalmology & visual science · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Article
- Superior Colliculus Controls the Activity of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in an Asymmetrical Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- The 6-OHDA Parkinson's Disease Mouse Model Shows Deficits in Sensory Behavior.bioRxiv : the preprint server for biology · 2025Article
- Basal ganglia components have distinct computational roles in decision-making dynamics under conflict and uncertainty.PLoS biology · 2025Article
- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- Dopaminergic computations for perceptual decisions.Current opinion in behavioral sciences · 2024Article
- Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories.Current biology : CB · 2024Article
- Temporal regularities shape perceptual decisions and striatal dopamine signals.Nature communications · 2024Article
- A feature-specific prediction error model explains dopaminergic heterogeneity.Nature neuroscience · 2024Article
- Analyzing the topological properties of resting-state brain function network connectivity based on graph theoretical methods in patients with high myopia.BMC ophthalmology · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.bioRxiv : the preprint server for biology · 2024Article
- Memory-specific encoding activities of the ventral tegmental area dopamine and GABA neurons.eLife · 2024Article
- Dopamine neuron activity encodes the length of upcoming contralateral movement sequences.Current biology : CB · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The striatum plays critical roles in visually-guided decision-making and receives dense axonal projections from midbrain dopamine neurons. However, the roles of striatal dopamine in visual decision-making are poorly understood. We trained male and female mice to perform a visual decision task with asymmetric reward payoff, and we recorded the activity of dopamine axons innervating striatum. Dopamine axons in the dorsomedial striatum (DMS) responded to contralateral visual stimuli and contralateral rewarded actions. Neural responses to contralateral stimuli could not be explained by orienting behavior such as eye movements. Moreover, these contralateral stimulus responses persisted in sessions where the animals were instructed to not move to obtain reward, further indicating that these signals are stimulus-related. Lastly, we show that DMS dopamine signals were qualitatively different from dopamine signals in the ventral striatum (VS), which responded to both ipsilateral and contralateral stimuli, conforming to canonical prediction error signaling under sensory uncertainty. Thus, during visual decisions, DMS dopamine encodes visual stimuli and rewarded actions in a lateralized fashion, and could facilitate associations between specific visual stimuli and actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.