ArticleProceedings of the National Academy of Sciences of the United States of America2021
Immunotherapy-based targeting of MSLN
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- From bench to bedside: Molecular mechanisms, diagnostic tools, and therapeutic strategies in liver fibrosis.Liver research (Beijing, China) · 2026Review
- Mesothelin biology and the evolving landscape of targeted immunotherapy.Molecular therapy. Oncology · 2026Review
- Mesothelin/Mucin 16 Signaling in Activated Portal Fibroblasts Drives the Development of Cholestatic Fibrosis and Hepatocellular Carcinoma in Aged Female Multidrug Resistance Protein 2 Knockout Mice.Cellular and molecular gastroenterology and hepatology · 2026Article
- Article
- Conserved Ductular Reaction Mechanisms in Biliary Atresia and Primary Sclerosing Cholangitis Derived From Single-Cell and Spatial Transcriptomics.Cellular and molecular gastroenterology and hepatology · 2026Review
- Novel perspectives on MSLN-targeted cancer therapy: from molecular mechanisms to clinical translation.Cancer biology & therapy · 2025Review
- Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice.Molecular medicine reports · 2025Article
- Mesothelin as a biomarker and potential therapeutic target in rheumatoid arthritis bone destruction.Cell reports. Medicine · 2025Article
- Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing.Journal of translational medicine · 2025Article
- The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols.Pharmacological reports : PR · 2024Review
- Article
- Aptamer-functionalized nanomaterials (AFNs) for therapeutic management of hepatocellular carcinoma.Journal of nanobiotechnology · 2024Review
- Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways.Journal of ginseng research · 2023Article
- Antifibrotic Soluble Thy-1 Correlates with Renal Dysfunction in Chronic Kidney Disease.International journal of molecular sciences · 2023Article
- How to calculate sample size in animal and human studies.Frontiers in medicine · 2023Review
- The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury.Biology · 2022Review
- Structure based innovative approach to analyze aptaprobe-GPC3 complexes in hepatocellular carcinoma.Journal of nanobiotechnology · 2022Article
- Thy-1-Integrin Interactions inFrontiers in cell and developmental biology · 2022Review
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Authors and funding
17 authors at 7 institutions in 3 countries.
Takahiro NishioDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.ORCID 0000-0002-9676-7235
Yukinori KoyamaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Xiao LiuDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.ORCID 0000-0002-7608-5819
Sara B RosenthalDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.
Gen YamamotoDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.
Hiroaki FujiDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.ORCID 0000-0003-1864-6005
Jacopo BaglieriDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.ORCID 0000-0002-5760-4812
Na LiDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.
Laura N BrennerPulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Keiko IwaisakoDepartment of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.ORCID 0000-0003-1977-8456
Kojiro TauraDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
James S HagoodProgram for Rare and Interstitial Lung Disease, Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0003-3938-0330
Nicholas F LaRussoCenter for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, MN 55905.ORCID 0000-0003-3266-0831
Tapan K BeraLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
Ira PastanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 pastani@mail.nih.gov tkisseleva@health.ucsd.edu.ORCID 0000-0002-9223-0270
David A BrennerDepartment of Medicine, University of California San Diego Medical Center, La Jolla, CA 92161.ORCID 0000-0003-2573-525X
Tatiana KisselevaDepartment of Surgery, University of California San Diego Medical Center, La Jolla, CA 92161; pastani@mail.nih.gov tkisseleva@health.ucsd.edu.
University of California San Diego Medical Center · USKyoto University · JPNational Cancer Institute · USDoshisha University · JPHarvard University · USMayo Clinic · USUniversity of North Carolina at Chapel Hill · US
Funding
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8MTargeting TGF-b Inhibitors and PPAR-y Agonists To Enhance IPF TherapyP01HL119165 · NHLBI · PROTEOGENOMICS RESEARCH INSTIT/SYS/ MED · PI HAGOOD, JAMES S. · 2015 to 2019
$13.6MREGULATION OF NFKB AND IKK BY PROINFLAMMATORY STIMULIR01AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL · 1998 to 2017
$7.4MNF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of InflammationR37AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin · 2018 to 2026
$6.0MInactivation of Hepatic Stellate Cells During Reversal of Liver FibrosisR01DK099205 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2014 to 2025
$4.8MThe Role of Portal Fibroblasts in Cholestatic Liver FibrosisR01DK101737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2014 to 2025
$3.8MNovel IL-23 inhibitor for the treatment of alcohol associated liver diseaseU01AA029019 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA, LOOMBA, ROHIT · 2020 to 2024
$3.7MEpigenetic Regulation of Alcoholic Liver FibrosisU01AA018663 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KISSELEVA, TATIANA, MANN, DEREK · 2010 to 2019
$3.7MThe role of IL-17 signaling in alcohol-induced HCCR01AA028550 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2021 to 2025
$2.3MThe Role of IL-17 in Alcoholic Liver Disease and CancerU01AA022614 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL, KISSELEVA, TATIANA · 2014 to 2018
$1.8MFibrocytes regulate liver fibrosisR01DK111866 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2017 to 2020
$1.4MThe Role of Fibrocytes in Liver FibrosisR56DK088837 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2012 to 2012
$194kNHLBI NIH HHS P01 HL119165NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA028550NIAAA NIH HHS U01 AA018663NIAAA NIH HHS U01 AA022614NIAAA NIH HHS U01 AA029019NIAID NIH HHS R01 AI043477NIAID NIH HHS R37 AI043477NIDDK NIH HHS F32 DK009920NIDDK NIH HHS R01 DK099205NIDDK NIH HHS R01 DK101737NIDDK NIH HHS R01 DK111866NIDDK NIH HHS R56 DK088837
Abstract
We investigated the role of mesothelin (Msln) and thymocyte differentiation antigen 1 (Thy1) in the activation of fibroblasts across multiple organs and demonstrated that Msln
Indexed as
ImmunotherapyAnimalsCholestasisCollagenFibroblastsHumansImmunotoxinsLiver CirrhosisMesothelinMiceThy-1 AntigensCollagenImmunotoxinsMesothelinMsln protein, mouseThy-1 Antigensactivated portal fibroblastscholestatic fibrosismesothelin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.