Evidence map›Paper›PMID 34253387›Full record

ArticleGynecologic oncology2021

Uptake of co-testing with HPV and cytology for cervical screening: A population-based evaluation in the United States.

Jack Cuzick, Ruofei Du, Rachael Adcock, Walter Kinney, Nancy Joste, Ruth M McDonald, Kevin English, Salina M Torres, Debbie Saslow, Cosette M Wheeler and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Gynecologic oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Use of Cancer Screening Tests, United States, 2023.Preventing chronic disease · 2025
    Article
  3. Article
  4. Article
  5. Cervical Cancer Screening Utilization among Kidney Transplant Recipients, 2001 to 2018.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 15 institutions in 2 countries.

Jack CuzickCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
Ruofei DuUniversity of New Mexico (UNM) Comprehensive Cancer Center, Department of Internal Medicine, Division of Molecular Medicine, Albuquerque, NM, USA.
Rachael AdcockCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
Walter KinneySacramento, CA, USA.
Nancy JosteUNM Health Sciences Center (HSC), Department of Pathology, Albuquerque, NM, USA.
Ruth M McDonaldUNM Health Sciences Center (HSC), Department of Pathology, Albuquerque, NM, USA; UNM Comprehensive Cancer Center, Center for HPV Prevention, Albuquerque, NM, USA.
Kevin EnglishAlbuquerque Area Southwest Tribal Epidemiology Center, Albuquerque, NM, USA.
Salina M TorresNew Mexico Department of Health, Albuquerque, NM, USA.
Debbie SaslowAmerican Cancer Society (ACS), Atlanta, GA, USA.
Cosette M WheelerUNM Health Sciences Center (HSC), Department of Pathology, Albuquerque, NM, USA; UNM Comprehensive Cancer Center, Center for HPV Prevention, Albuquerque, NM, USA. Electronic address: cwheeler@salud.unm.edu.
New Mexico HPV Pap Registry Steering Committee
University of New Mexico · USNew Mexico Department of Health · USQueen Mary University of London · GBUNM Comprehensive Cancer CenterAmerican Cancer Society · USIndian Health Service · USTrinity Southwest University · USAlbert Einstein College of Medicine · USBoston University · USCalifornia State University, Sacramento · USCenters for Disease Control and Prevention · USHarvard University · USNew Mexico Cancer Center · USSacramento City College · USUniversity of Virginia · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
The EPI-STI Biostatistics and Bioinformatics Core (Cuzick/Wheeler)U19AI113187 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI WHEELER, COSETTE MARIE · 2014 to 2018
$12.6M
NCI NIH HHS P30 CA118100NIAID NIH HHS U19 AI113187
6 · The paper itself

Abstract

objectivesHuman papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by national and international bodies.

methodsRegistry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology.

resultsA total of 1,704,055 cervical screening tests from 681,440 women aged 21-64 years in the state of New Mexico were identified. The proportion of screening tests which were co-tests rose from 5.6% in 2008 to 84.3% in 2019 among women aged 30-64 years with a marked change from the near exclusive use of the Hybrid Capture II HPV test, (a signal amplified test method) to the use of target amplified HPV tests. The largest increases were seen between 2013 and 2015, reflecting the introduction and adoption of new clinical guidelines. Increases in co-testing were also seen in younger women.

conclusionsCo-testing is now well established in women aged 30-64 years, but smaller increases have also been seen at younger ages, although this is not currently recommended. The impact of co-testing on cervical disease outcomes and number of colposcopies and biopsies in routine population settings remain important, especially in young women.

Indexed as

AdultCervix UteriEarly Detection of CancerFemaleHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsPrecancerous ConditionsRegistriesUnited StatesUterine Cervical NeoplasmsYoung Adult

Identifiers

PMID34253387
PMCPMC8405560
OpenAlexW3181409999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.