ArticleeLife2021
Neural correlates of ingroup bias for prosociality in rats.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice.eNeuro · 2026Article
- Individual differences in prosocial learning are represented in the hippocampal dorsal CA1.Nature neuroscience · 2026Article
- Neural correlates of adversity-overcoming pup rescue behavior in female mice.Scientific reports · 2026Article
- Article
- The entactogen MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") disrupts helping behaviour while reinforcing electrophysiological indicators of potentially associated synaptic plasticity in male Sprague-Dawley rats.Frontiers in pharmacology · 2026Article
- Mapping brain-wide activity networks: brainways as a tool for neurobiological discovery.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles.Hormones and behavior · 2025Article
- Neural and Behavioral Correlates of Individual Variability in Rat Helping Behavior: A Role for Social Affiliation and Oxytocin Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Oxytocin effects on socially transmitted food preferences are moderated by familiarity between rats.Psychopharmacology · 2025Article
- Exploring rodent prosociality: A conceptual framework.Translational neuroscience · 2025Review
- Norway rats recruit cooperation partners based on previous receipt of help while disregarding kinship.iScience · 2024Article
- Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups.Current biology : CB · 2024Article
- Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats.Cognitive neurodynamics · 2024Article
- Prior Negative Experience Biases Activity of Medial Amygdala during Interstrain Social Engagement in Male Rats.eNeuro · 2024Article
- The beneficial effects of social support and prosocial behavior on immunity and health: A psychoneuroimmunology perspective.Brain, behavior, & immunity - health · 2024Article
- In search of prosociality in rodents: A scoping review.PloS one · 2024Article
- Neuronal, affective, and sensory correlates of targeted helping behavior in male and female Sprague Dawley rats.Frontiers in behavioral neuroscience · 2024Article
- Racism is not about "race".Scientific reports · 2023Article
- Vicarious Emotions of Fear and Pain in Rodents.Affective science · 2023Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosocial behavior, in particular helping others in need, occurs preferentially in response to distress of one's own group members. In order to explore the neural mechanisms promoting mammalian helping behavior, a discovery-based approach was used here to identify brain-wide activity correlated with helping behavior in rats. Demonstrating social selectivity, rats helped others of their strain ('ingroup'), but not rats of an unfamiliar strain ('outgroup'), by releasing them from a restrainer. Analysis of brain-wide neural activity via quantification of the early-immediate gene c-Fos identified a shared network, including frontal and insular cortices, that was active in the helping test irrespective of group membership. In contrast, the striatum was selectively active for ingroup members, and activity in the nucleus accumbens, a central network hub, correlated with helping. In vivo calcium imaging showed accumbens activity when rats approached a trapped ingroup member, and retrograde tracing identified a subpopulation of accumbens-projecting cells that was correlated with helping. These findings demonstrate that motivation and reward networks are associated with helping an ingroup member and provide the first description of neural correlates of ingroup bias in rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.