Evidence map›Paper›PMID 34253250›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2021

A national study of choanal atresia in tertiary care centers in Canada - part I: clinical presentation.

Josee Paradis, Agnieszka Dzioba, Hamdy El-Hakim, Paul Hong, Frederick K Kozak, Lily H P Nguyen, Demitri Perera, Evan Jon Propst, Jennifer M Siu, Monika Wojtera and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Josee ParadisDepartment of Otolaryngology- Head and Neck Surgery, Children's Hospital at London Health Sciences Centre, London, ON, Canada. Josee.Paradis@lhsc.on.ca.
Agnieszka DziobaDepartment of Otolaryngology- Head and Neck Surgery, Children's Hospital at London Health Sciences Centre, London, ON, Canada.
Hamdy El-HakimDivision of Pediatric Surgery and Otolaryngology Head and Neck Surgery, Departments of Surgery and Pediatrics, The Stollery Children's Hospital, University of Alberta Hospital, Edmonton, AB, Canada.
Paul HongIWK Health Centre, Halifax, NS, Canada.
Frederick K KozakFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Lily H P NguyenDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Canada.
Demitri PereraFaculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Evan Jon PropstDepartment of Otolaryngology-Head & Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jennifer M SiuDepartment of Otolaryngology-Head & Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Monika WojteraOtolaryngology-Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Murad HuseinDepartment of Otolaryngology- Head and Neck Surgery, Children's Hospital at London Health Sciences Centre, London, ON, Canada.
National Choanal Atresia Study Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the clinical presentation of choanal atresia (CA) in tertiary centers across Canada.

methodsMulti-centre case series involving six tertiary care pediatric hospitals across Canada. Retrospective chart review of patients born between 1980 and 2010 diagnosed with CA at a participating center.

resultsThe health charts of 215 patients (59.6% female) with CA were reviewed and included in this study. The mean age of patients at time of CA presentation was 0.4 months (range 0.1 to 7.2 months) for bilateral CA and 37.8 months (range 0.1 to 164.1 months) for unilateral cases. The most common presenting symptoms for bilateral CA in decreasing order were respiratory distress (96.4%), feeding difficulties (68.2%), and rhinorrhea (65.5%), and for unilateral cases in decreasing order were rhinorrhea (92.0%), feeding difficulties (24.7%), and respiratory distress (18.0%). For the majority of patients (73.2%), the obstruction comprised mixed bony and membranous tissue, with only 10.5% presenting with a purely membranous obstruction. Familial history of CA was confirmed in only 3.3% of cases. One half of patients with CA presented with one or more associated anomalies and 30.6% had a syndrome.

conclusionsThe present investigation is the first national multi-institutional study evaluating the clinical presentation of CA over three decades. The present cohort of CA patients presented with a breadth of co-morbidities with highly variable presentations, with bilateral cases being more severely affected than unilateral cases. Further investigation into hereditary linkages to CA development is warranted.

Indexed as

Choanal AtresiaCanadaChildFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesTertiary Care CentersChoanal atresiaClinical presentationFamily history

Identifiers

PMID34253250
PMCPMC8274042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.