ArticleGenome biology2021
Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 89 citations in OpenAlex.
- Same Sex Chromosomes With Independent Origins in Haplochromine Cichlids.Genome biology and evolution · 2026Article
- EasyCen: A Lightweight Framework for Centromere Localisation and Repeat-Organisation Profiling in Telomere-to-Telomere Genomes.Molecular ecology resources · 2026Article
- Gap-free telomere-to-telomere genome assembly of stone flounder (Kareius bicoloratus).Scientific data · 2026Article
- Integrated Transcriptome Landscape of mRNAs, lncRNAs, circRNAs, and miRNAs Reveals Molecular Regulatory Networks of Sex Differentiation in the Zig-Zag Eel (International journal of molecular sciences · 2026Article
- Genetic Diversity and Differentiation Pattern ofBiology · 2026Article
- The near telomere-to-telomere genome of the Murray cod (Maccullochella peelii).Scientific data · 2026Article
- Telomere-to-telomere gapless genome assembly of Siniperca scherzeri.Scientific data · 2026Article
- Sex-Specific Marker Development and Identification of an XY Sex Determination System in the Tire Track Eel (Animals : an open access journal from MDPI · 2026Article
- Near telomere-to-telomere diploid genome assembly of Acrossocheilus wenchowensis.Scientific data · 2026Article
- Gap-Free T2T assemblies of Micropterus salmoides identify a Y-Linked SV hotspot underlying sexual dimorphism.BMC genomics · 2025Article
- Whole-genome resequencing reveals chromosomal fusion-driven early stages of XY chromosomes evolution in the darkbarbel catfish (Tachysurus vachellii).Frontiers in zoology · 2025Article
- T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gap-free telomere-to-telomere genome assembly of marbled flounder (Pseudopleuronectes yokohamae).Scientific data · 2025Article
- Agptools: a utility suite for editing genome assemblies.Bioinformatics (Oxford, England) · 2025Article
- Evidence for evolution of a new sex chromosome within the haploid-dominant Marchantiales plant lineage.Journal of integrative plant biology · 2025Article
- Assembly and analysis of Sinipercidae fish sex chromosomes reveals that a supergene drives sex chromosome origin and turnover.Advanced biotechnology · 2025Article
- The telomere-to-telomere genome assembly and annotation of the rock carp (Procypris rabaudi).Scientific data · 2025Article
- Allelic variation and duplication of the dmrt1 were associated with sex chromosome turnover in three representative Scatophagidae fish species.Communications biology · 2025Article
- The Cause-Effect Model of Master Sex Determination Gene Acquisition and the Evolution of Sex Chromosomes.International journal of molecular sciences · 2025Review
- Telomere-to-telomere genome assembly of Electrophorus electricus provides insights into the evolution of electric eels.GigaScience · 2025Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe origin of sex chromosomes requires the establishment of recombination suppression between the proto-sex chromosomes. In many fish species, the sex chromosome pair is homomorphic with a recent origin, providing species for studying how and why recombination suppression evolved in the initial stages of sex chromosome differentiation, but this requires accurate sequence assembly of the X and Y (or Z and W) chromosomes, which may be difficult if they are recently diverged.
resultsHere we produce a haplotype-resolved genome assembly of zig-zag eel (Mastacembelus armatus), an aquaculture fish, at the chromosomal scale. The diploid assembly is nearly gap-free, and in most chromosomes, we resolve the centromeric and subtelomeric heterochromatic sequences. In particular, the Y chromosome, including its highly repetitive short arm, has zero gaps. Using resequencing data, we identify a ~7 Mb fully sex-linked region (SLR), spanning the sex chromosome centromere and almost entirely embedded in the pericentromeric heterochromatin. The SLRs on the X and Y chromosomes are almost identical in sequence and gene content, but both are repetitive and heterochromatic, consistent with zero or low recombination. We further identify an HMG-domain containing gene HMGN6 in the SLR as a candidate sex-determining gene that is expressed at the onset of testis development.
conclusionsOur study supports the idea that preexisting regions of low recombination, such as pericentromeric regions, can give rise to SLR in the absence of structural variations between the proto-sex chromosomes.
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