Evidence map›Paper›PMID 34253077›Full record

ArticleBehavior modification2022

Amplification of Positivity Therapy for Co-occurring Alcohol Use Disorder with Depression and Anxiety Symptoms: Pilot Feasibility Study and Case Series.

Elisabeth Akeman, Evan White, Kate Wolitzky-Taylor, Jessica Santiago, Timothy J McDermott, Danielle C DeVille, Jennifer L Stewart, Martin Paulus, Charles T Taylor, Robin L Aupperle

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Behavior modification, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04278365 nacompletednot on this map

Affective Modulation of Positivity for Alcohol Use Disorder (AMP-A): Feasibility and Pilot Study

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2019 to 2020Enrolled8ConditionsAnxiety, Depression, Alcohol Use DisorderArmsPositive affect training
NCT06030154 narecruitingnot on this mapstarted 2023, after this paper: background citation

Developing and Evaluating a Positive Valence Treatment for Alcohol Use Disorder With Anxiety or Depression

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2023 to 2026Enrolled100ConditionsAlcohol Use Disorder, Anxiety, DepressionArmsCognitive Behavioral Therapy, Amplification of Positivity Therapy, Surveys and Interviews
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Elisabeth AkemanLaureate Institute for Brain Research, Tulsa, OK, USA.
Evan WhiteLaureate Institute for Brain Research, Tulsa, OK, USA.
Kate Wolitzky-TaylorUniversity of Southern California, Los Angeles, USA.ORCID 0000-0001-6199-4350
Jessica SantiagoLaureate Institute for Brain Research, Tulsa, OK, USA.
Timothy J McDermottLaureate Institute for Brain Research, Tulsa, OK, USA.
Danielle C DeVilleLaureate Institute for Brain Research, Tulsa, OK, USA.
Jennifer L StewartLaureate Institute for Brain Research, Tulsa, OK, USA.
Martin PaulusLaureate Institute for Brain Research, Tulsa, OK, USA.
Charles T TaylorUniversity of California San Diego, La Jolla, USA.
Robin L AupperleLaureate Institute for Brain Research, Tulsa, OK, USA.ORCID 0000-0003-2173-6140
Laureate Institute for Brain Research · USUniversity of California San Diego · USUniversity of Southern California · US

Funding

Plasticity of Aversive Salience in Opioid Use DisorderR01DA050677 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI STEWART, JENNIFER LORRAINE · 2021 to 2025
$3.0M
An Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome in Anxiety and DepressionR01MH123691 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI AUPPERLE, ROBIN L · 2020 to 2024
$2.6M
Approach-Avoidance Conflict-a multi-level predictor for exposure therapy responseK23MH108707 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI AUPPERLE, ROBIN L · 2016 to 2020
$976k
Self-regulation of Prefrontal Cortex during Emotional Cognitive ControlF31MH122090 · NIMH · UNIVERSITY OF TULSA · PI MCDERMOTT, TIMOTHY · 2020 to 2022
$102k
NIDA NIH HHS R01 DA050677NIMH NIH HHS F31 MH122090NIMH NIH HHS K23 MH108707NIMH NIH HHS R01 MH123691
6 · The paper itself

Abstract

Positive valence system dysregulation is a relatively unexplored transdiagnostic mechanism and potential treatment target underpinning alcohol use and anxiety and depression symptoms. The current study examined the feasibility and potential benefit of a behavioral intervention focused on amplification of positivity (AMP) with eight adults (five female) diagnosed with alcohol use disorder and clinically significant depression or anxiety (ClinicalTrials.gov: NCT04278365). AMP for alcohol use (AMP-A) was delivered in 11 individual sessions involving positive activity interventions integrated alongside psychoeducation and alcohol use monitoring. Case descriptions are provided to illustrate treatment implementation. Treatment credibility and acceptability, participant endorsement of the therapy, and homework compliance were rated moderate to high. Exploratory, intent-to-treat analyses suggested medium to large effect sizes for post-treatment improvements in alcohol use, depression, anxiety, and positive affect. Results provide initial evidence of feasibility and acceptability of AMP-A and will be useful for informing future randomized clinical trials to examine clinical efficacy.

Indexed as

AlcoholismCognitive Behavioral TherapyAdultAnxietyDepressionFeasibility StudiesFemaleHumansalcohol useanxietycognitive-behavioral therapydepressionpositive affect

Identifiers

PMID34253077
PMCPMC8752639
OpenAlexW3183083647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.