Evidence map›Paper›PMID 34253061›Full record

ArticlemBio2021

Pneumococcal Extracellular Vesicles Modulate Host Immunity.

Saigopalakrishna S Yerneni, Sarah Werner, Juliana H Azambuja, Nils Ludwig, Rory Eutsey, Surya D Aggarwal, Peter C Lucas, Nathanael Bailey, Theresa L Whiteside, Phil G Campbell and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Identification of immunostimulatory antigens in Group AProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Extracellular Vesicles fromMicroorganisms · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Novel processes to obtain pneumococcal surface proteins for vaccines.Applied microbiology and biotechnology · 2025
    Review
  13. Immunostimulatory effects ofInfection and immunity · 2025
    Article
  14. Journal of oral microbiology · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Autophagy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Saigopalakrishna S YerneniDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Sarah WernerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Juliana H AzambujaUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nils LudwigUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rory EutseyDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Surya D AggarwalDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Peter C LucasUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nathanael BaileyDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Theresa L WhitesideUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Phil G CampbellDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
N Luisa HillerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Carnegie Mellon University · USUniversity of Pittsburgh · US

Funding

Depleting exosomes to improve responses to immune therapy in HNSCCU01DE029759 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2020 to 2024
$3.5M
NIDCR NIH HHS U01 DE029759
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have recently garnered attention for their participation in host-microbe interactions in pneumococcal infections. However, the effect of EVs on the host immune system remain poorly understood. Our studies focus on EVs produced by

Indexed as

AnimalsExtracellular VesiclesFemaleHost-Pathogen InteractionsMacrophagesMaleMiceMice, Inbred C57BLPhagocytosisPhenotypePneumococcal InfectionsSignal TransductionStreptococcus pneumoniaealternative activation pathwayEVsextracellular vesiclesGram-positive bacteriahost-pathogen interactionsimmune responsemacrophage signalingpathogenesisStreptococcus pneumoniae

Identifiers

PMID34253061
PMCPMC8406339
OpenAlexW3179125990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.