ArticlemBio2021
Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4
Open access · goldAbstract read
In one paragraph
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Immunological mechanistic action of intravenous BCG-mediated protection against tuberculosis.Cellular and molecular life sciences : CMLS · 2026Review
- Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis.Frontiers in nutrition · 2026Article
- Saponin TQL1055 adjuvant-containing vaccine confers protection uponHuman vaccines & immunotherapeutics · 2024Article
- Permissive lung neutrophils facilitate tuberculosis immunopathogenesis in male phagocyte NADPH oxidase-deficient mice.PLoS pathogens · 2024Article
- Article
- A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y.PLoS pathogens · 2024Article
- Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection.PLoS pathogens · 2024Article
- Article
- Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control.Nature immunology · 2023Article
- Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection againstVirulence · 2022Article
- Mycobacterium tuberculosis infection drives a type I IFN signature in lung lymphocytes.Cell reports · 2022Article
- Leveraging Antibody, B Cell and Fc Receptor Interactions to Understand Heterogeneous Immune Responses in Tuberculosis.Frontiers in immunology · 2022Review
- Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model.Frontiers in pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 4 countries.
Shibali Das *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nancy D Marin *Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ekaterina EsaulovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Mushtaq AhmedDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Amanda SwainDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Bruce A RosaDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Makedonka MitrevaDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Javier Rangel-MorenoDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA.
Mihai G NeteaDepartment of Internal Medicine, Radboudumc Center for Infectious Diseases, Nijmegen, Netherlands.
Luis B BarreiroDepartment of Medicine, Genetic Section, University of Chicago, Chicago, Illinois, USA.
Maziar DivangahiMeakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, McGill University Health Centre and McGill International TB Centre, McGill University, Montreal, Quebec, Canada.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Deepak KaushalSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · USJames S. McDonnell Foundation · USMcGill University Health Centre · CATexas Biomedical Research Institute · USUniversity of Bonn · DEUniversity of Chicago · USUniversity of Rochester Medical Center · US
Funding
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MViral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHELLEY A COLE · 2012 to 2026
$35.6MUniversiity of Rochester Center for Medical Countermeasures against RadiationU19AI091036 · NIAID · UNIVERSITY OF ROCHESTER · PI WILLIAMS, JACQUELINE PATRICIA · 2010 to 2014
$15.6MROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1MROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9MImmune Correlates of Protection from TBR01AI134240 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2017 to 2022
$4.8MThe Role of Group 3 Innate Lymphoid cells (ILC3) in TuberculosisR01AI134236 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, KHADER, SHABAANA A. · 2017 to 2021
$4.4MCOMMON IMMUNE CORRELATES OF RISK OF TB DISEASE IN ANIMAL MODELS AND HUMANSR01AI123780 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2016 to 2019
$2.9MNHLBI NIH HHS R01 HL105427NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI123780NIAID NIH HHS R01 AI134236NIAID NIH HHS R01 AI134240NIAID NIH HHS U19 AI091036NIH HHS P51 OD011133NIH HHS U42 OD010442
Abstract
Tuberculosis (TB) is one of the leading causes of death due to a single infectious agent. The development of a TB vaccine that induces durable and effective immunity to Mycobacterium tuberculosis (
Indexed as
Lymphocyte ActivationAnimalsBCG VaccineCD4-Positive T-LymphocytesEpithelial CellsImmunity, InnateLungMiceMice, Inbred C57BLMycobacterium tuberculosisSignal TransductionTuberculosisVaccinationBCG Vaccineclonalitycytokinesdendritic cellsepithelial cellslung infectionMycobacterium tuberculosisparenchymatuberculosisvaccine-induced response
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.