ArticlemBio2021
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 100 citations in OpenAlex.
- Infection of urban rodents by SARS-CoV-2 in COVID-19 healthcare facilities in Brazzaville, Republic of the Congo.One health outlook · 2026Article
- mRNA Vaccines Targeting the Conserved SARS-CoV-2 Fusion Machinery Elicit Cross-Variant and Robust Immunity.Vaccines · 2026Article
- Sex differences in immune responses to viruses, bacteria and vaccines.Nature immunology · 2026Review
- Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling.Nature communications · 2026Article
- Understanding sex and gender disparities in COVID-19 mortality: a narrative review beyond biology.Biology of sex differences · 2025Review
- Mechanisms of sex differences in acute and long COVID sequelae in mice.bioRxiv : the preprint server for biology · 2025Article
- Severe acute respiratory syndrome coronavirus 2-mediated dysregulation of drug processing genes is dependent on pathogenic variants, target site of infection, age, and sex.Drug metabolism and disposition: the biological fate of chemicals · 2025Article
- Article
- Pregnancy reduces COVID-19 vaccine immunity against novel variants.NPJ vaccines · 2025Article
- Optimization of a panel of behavioral tests for use in containment using a golden Syrian hamster model.Journal of virological methods · 2025Article
- Guinea Pigs Are Not a Suitable Model to Study Neurological Impacts of Ancestral SARS-CoV-2 Intranasal Infection.Viruses · 2025Article
- A third COVID-19 vaccine dose in kidney transplant recipients induces antibody response to vaccine and Omicron variants but shows limited Ig subclass switching.Microbiology spectrum · 2025Article
- Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis.Nature communications · 2025Article
- Barcoded SARS-CoV-2 viruses define the impact of duration and route of exposure on the transmission bottleneck in a hamster model.Science advances · 2025Article
- Review
- Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.Virulence · 2024Review
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- SARS-CoV-2 infection results in a unique lung proteome long after virus resolution in the hamster.Npj viruses · 2024Article
- SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia.International journal of molecular sciences · 2024Article
- Barcoded SARS-CoV-2 viruses define the impact of time and route of transmission on the transmission bottleneck in a Syrian hamster model.bioRxiv : the preprint server for biology · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
31 authors at 1 institution in 1 country.
Santosh Dhakal *W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Camilo A Ruiz-Bedoya *Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA.
Ruifeng ZhouW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Patrick S CreisherW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jason S VillanoDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kirsten LittlefieldW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jennie Ruelas CastilloDepartment of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Paula MarinhoW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Anne E JedlickaW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Alvaro A OrdonezDepartment of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA.
Melissa BahrDepartment of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA.
Natalia MajewskaAdvanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7, Baltimore, Maryland, USA.
Michael J BetenbaughAdvanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7, Baltimore, Maryland, USA.
Kelly FlavahanDepartment of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA.
Alice R L MuellerW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Monika M LooneyDepartment of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Darla QuijadaDepartment of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Filipa MotaDepartment of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA.
Sarah E BeckDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Jacqueline BrockhurstDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Alicia M BraxtonDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Natalie CastellDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Mitchel StoverDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Franco R D'AlessioDepartment of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kelly A Metcalf PateDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Petros C KarakousisDepartment of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Joseph L MankowskiDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Sanjay K JainDepartment of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA.
Sabra L KleinW. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Johns Hopkins COVID-19 Hamster Study Group
Johns Hopkins University · US
Funding
Virology Resource CoreU54CA260492 · NCI · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L, KLEIN, SABRA L. · 2020 to 2024
$10.4MSex differences in the impact of frailty on vaccine-induced immune responses in community-dwelling older adultsU54AG062333 · NIA · JOHNS HOPKINS UNIVERSITY · PI KLEIN, SABRA L. · 2018 to 2022
$8.9MTraining Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7MMeasuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8MNCI NIH HHS U54 CA260492NIAID NIH HHS HHSN272201400007CNIAID NIH HHS R01 AI153349NIA NIH HHS U54 AG062333NIH HHS T32 OD011089
Abstract
In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in males than in females, including hospitalizations and deaths. Animal models can provide an opportunity to mechanistically interrogate causes of sex differences in the pathogenesis of SARS-CoV-2. Adult male and female golden Syrian hamsters (8 to 10 weeks of age) were inoculated intranasally with 10
Indexed as
Severity of Illness IndexAnimalsAntibodies, ViralAntibody FormationCOVID-19CricetinaeDisease Models, AnimalEstradiolFemaleImmunoglobulin AImmunoglobulin GImmunoglobulin MInterferon-betaLungMaleSARS-CoV-2Antibodies, ViralEstradiolImmunoglobulin AImmunoglobulin GImmunoglobulin MInterferon-betaSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Tumor Necrosis Factor-alphaanimal modelCOVID-19receptor-binding domainSARS-CoV-2 variantssex differences
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.