Evidence map›Paper›PMID 34252887›Full record

SynthesisJournal of breath research2021

Medical diagnosis at the point-of-care by portable high-field asymmetric waveform ion mobility spectrometry: a systematic review and meta-analysis.

J Diana Zhang, Merryn J Baker, Zhixin Liu, K M Mohibul Kabir, Vijaya B Kolachalama, Deborah H Yates, William A Donald

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of breath research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

J Diana ZhangSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID 0000-0002-1464-7644
Merryn J BakerSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID 0000-0003-3907-1298
Zhixin LiuStats Central, University of New South Wales, Sydney, Australia.ORCID 0000-0003-3337-0692
K M Mohibul KabirSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID 0000-0003-3742-5742
Vijaya B KolachalamaSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Computer Science and Faculty of Computing and Data Sciences, Boston University, Boston, MA, United States of America.ORCID 0000-0002-5312-8644
Deborah H YatesDepartment of Thoracic Medicine, St Vincent's Hospital and St Vincent's Clinical School, UNSW Sydney, Sydney, Australia.ORCID 0000-0001-6419-6856
William A DonaldSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID 0000-0002-6622-8193
UNSW Sydney · AUBoston University · USSt Vincent's Clinic · AU

Funding

Mechanisms of drug-coated balloon therapyR01HL159620 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOLACHALAMA, VIJAYA B. · 2021 to 2024
$2.1M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
PRISTINE: Pre-cancer histology identification of Endobronchial biopsies using deep learningR21CA253498 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BEANE, JENNIFER ELLEN, KOLACHALAMA, VIJAYA B. · 2020 to 2020
$424k
Smartphone image analysis for real time adequacy assessment during kidney biopsyR43DK134273 · NIDDK · NEPHROPATHOLOGY ASSOCIATES · PI KOLACHALAMA, VIJAYA B., SHARMA, SHREE GOPAL · 2022 to 2022
$252k
NCI NIH HHS R21 CA253498NHLBI NIH HHS R01 HL159620NIA NIH HHS RF1 AG062109NIDDK NIH HHS R43 DK134273
6 · The paper itself

Abstract

Non-invasive medical diagnosis by analysing volatile organic compounds (VOCs) at the point-of-care is becoming feasible owing to recent advances in portable instrumentation. A number of studies have assessed the performance of a state-of-the-art VOC analyser (micro-chip high-field asymmetric waveform ion mobility spectrometry, FAIMS) for medical diagnosis. However, a comprehensive meta-analysis is needed to investigate the overall diagnostic performance of these novel methods across different medical conditions. An electronic search was performed using the CAplus and MEDLINE database through the SciFinder platform. The review identified a total of 23 studies and 2312 individuals. Eighteen studies were used for meta-analysis. A pooled analysis found an overall sensitivity of 80% (95% CI, 74%-85%,

Indexed as

Ion Mobility SpectrometryVolatile Organic CompoundsBreath TestsHumansPoint-of-Care SystemsSensitivity and SpecificityVolatile Organic Compoundsdisease diagnosisFAIMSion mobilitymachine learningpoint-of-care testingVOC analysis

Identifiers

PMID34252887
PMCPMC10422980
OpenAlexW3182837217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.