Evidence map›Paper›PMID 34252832›Full record

SynthesisEpilepsy & behavior : E&B2021

A systematic literature review of health disparities among rural people with epilepsy (RPWE) in the United States and Canada.

Sean M Duke, Karina A González Otárula, Thomas Canales, Elaine Lu, Amber Stout, Gena R Ghearing, Martha Sajatovic

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Epilepsy & behavior : E&B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sean M DukeDepartment of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 10900 Euclid Ave., Cleveland, OH 44106, USA. Electronic address: sean.duke@uhhospitals.org.
Karina A González OtárulaDepartment of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Thomas CanalesDepartment of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 10900 Euclid Ave., Cleveland, OH 44106, USA.
Elaine LuDepartment of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 10900 Euclid Ave., Cleveland, OH 44106, USA.
Amber StoutDepartment of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 10900 Euclid Ave., Cleveland, OH 44106, USA.
Gena R GhearingDepartment of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Martha SajatovicDepartment of Neurology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 10900 Euclid Ave., Cleveland, OH 44106, USA.
University Hospitals of Cleveland · USUniversity of Iowa · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
University of Iowa Prevention Research Center for Rural HealthU48DP006389 · DP · UNIVERSITY OF IOWA · PI AFIFI, RIMA · 2018 to 2023
$7.4M
Reducing the Burden of Chronic Psychotic Disorders in TanzaniaR21MH114700 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MBWAMBO, JESSIE K, SAJATOVIC, MARTHA X · 2017 to 2018
$348k
ACL HHS U48DP006389NCATS NIH HHS UL1 TR002537NCATS NIH HHS UL1 TR002548NCCDPHP CDC HHS U48 DP006389NIMH NIH HHS R21 MH114700
6 · The paper itself

Abstract

backgroundEpilepsy is a leading cause of global disease burden, with people with epilepsy (PWE) experiencing adverse health outcomes related to the psychiatric comorbidities and socioeconomic consequences of the disorder. Rural populations are more likely to be impoverished or uninsured, which could impact health outcomes for rural-dwelling PWE (RPWE).

aimsThis systematic literature review identified original research studying health disparities and outcomes among RPWE in the United States and Canada to (1) characterize the disparities faced by RPWE and (2) elucidate the effects of these disparities upon clinical outcomes.

methodsWe performed a systematic search of six electronic databases: Pubmed, Cochrane, PsychInfo, Web of Science, Scopus, and Ovid. Articles considered were original research reports conducted in Canada or the United States before August 2020. A modified Newcastle Ottawa Scale was used to assess the quality of the included studies.

resultsOur search returned 2093 articles that examined the health disparities of RPWE, of which six met criteria for this review. Outcome measures of health disparity included in these papers were mortality (2; 33%), use of health resources (2; 33%), and epilepsy prevalence (2; 33%). Only one paper (16%) concluded that RPWE experienced worse health outcomes relative to urban-dwelling PWE, while 5 (84%) found no difference.

conclusionOur study did not find sufficient evidence that RPWE in the US and Canada experience significant health disparities compared to similar urban populations of PWE. More research using prospective studies and datasets allowing better characterization of rurality is required.

Indexed as

EpilepsyRural PopulationCanadaHumansProspective StudiesUnited StatesUrban PopulationEpilepsyInequitiesMortalityRuralUnder-served

Identifiers

PMID34252832
PMCPMC8429139
OpenAlexW3178977641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.